estrone

1. cytochrome P450 (estrone)

Catalysed by CYP3A4cytosolOne of 4 routes

1. UDPglucuronate beta-D-glucuronosyltransferase(acceptor-unspecific)

Catalysed by UGT1A1, UGT1A10, UGT1A8endoplasmic reticulumOne of 2 routes

1. Estradiol-17beta:NADP+ 17-oxidoreductase

Catalysed by HSD17B6, HSD17B1, HSD17B2, HSD17B7 and 3 morecytosolOne of 5 routes

1. 17alpha-estradiol + NADP(+) = estrone + NADPH + H(+)

Catalysed by DHRS1

1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase

Catalysed by SULT1A3, SULT1E1, SULT1A1cytosolOne of 3 routes

1. unspecific monooxygenase (estrone)

Catalysed by CYP1A1, CYP1A2, CYP2E1, CYP3A4 and 20 morecytosolOne of 3 routes

1. estrone + reduced [NADPH--hemoprotein reductase] + O2 = 4-hydroxyestrone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP1A1, CYP1A2, CYP3A4, CYP3A5 and 2 more

1. estrone + reduced [NADPH--hemoprotein reductase] + O2 = 6alpha-hydroxyestrone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP1A1

1. estrone + reduced [NADPH--hemoprotein reductase] + O2 = 15alpha-hydroxyestrone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP1A1

1. cytochrome P450 (estrone)
2. S-adenosyl-L-methionine:2-Hydroxyestrone O-methyltransferase

Catalysed by CYP3A4, COMT, LRTOMTcytosolOne of 3 routes

1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
2. transport of estrone 3-sulfate (cytosol to extracellular)

Catalysed by SULT1A3, SULT1E1, SULT1A1, SLCO1B1cytosol, extracellular space

1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
2. transport of estrone 3-sulfate (cytosol to extracellular)
3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

Catalysed by SULT1A3, SULT1E1, SULT1A1, SLCO1B1 and 2 morecytosol, extracellular spaceOne of 2 routes

1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
2. transport of estrone 3-sulfate (cytosol to extracellular)
3. transport of glycoursodeoxycholate (cytosol to extracellular)