D-arginine

Three steps

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by SLC25A2, GATM, GARTinner side of the membrane, outer side of the membrane, cytosol

• L-cystine-bis-glycineReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by SLC25A2, GATM, DPEP1, DPEP2inner side of the membrane, outer side of the membrane, cytosol

• glycyldehydrophenylalanineReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by SLC25A2, GATM, DPEP1inner side of the membrane, outer side of the membrane, cytosol

• 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)

  Catalysed by SLC25A2, SLC7A6, PFASinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• kinetensinReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. Chymase

  Catalysed by SLC25A2, SLC7A6, CMA1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• an N-(fatty acyl)-glycineReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by SLC25A2, GATM, GLYATL2inner side of the membrane, outer side of the membrane, cytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by SLC25A2, GATM, GLYATL2inner side of the membrane, outer side of the membrane, cytosol

• acetaldehydeReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of ornithine and threonine (cytosol to extracellular)
  3. L-threonine acetaldehyde-lyase (glycine-forming)

  Catalysed by SLC25A2, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• pyruvateReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC25A2, SLC7A6, AGXT2inner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrixOne of 17 routes

• 4a-hydroxytetrahydrobiopterinReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase(5-hydroxylating)

  Catalysed by SLC25A2, SLC7A6, TPH1, TPH2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• CHEBI:15570Reach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by SLC25A2, GATM, SLC3A2, SLC7A10inner side of the membrane, outer side of the membrane, cytosol, extracellular spaceOne of 5 routes

• CHEBI:15611Reach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by SLC25A2, GATM, GNMTinner side of the membrane, outer side of the membrane, cytosol

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by SLC25A2, SLC7A6, TPH1, TPH2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• trimethylenediamineReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of lysine and ornithine (cytosol to extracellular)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by SLC25A2, SLC7A5, SLC7A6, DHPSinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• CHEBI:15727Reach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of histidine and ornithine (cytosol to extracellular)
  3. L-histidine:beta-alanine ligase (ADP-forming)

  Catalysed by SLC25A2, SLC7A5, SLC7A6, CARNS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• CHEBI:15765Reach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of ornithine and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by SLC25A2, SLC7A6, THinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 5 routes

• alpha-D-glucosamine 6-phosphateReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by SLC25A2, SLC7A6, GFPT2, GFPT1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• ureaReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. L-Arginine amidinohydrolase

  Catalysed by SLC25A2, GATM, ARG1inner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• L-cystineReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)

  Catalysed by SLC25A2, GATM, SLC7A9inner side of the membrane, outer side of the membrane, cytosolOne of 7 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC25A2, SLC7A6, AGXT2inner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix

• iodideReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of ornithine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by SLC25A2, SLC7A6, TPOinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• nitric oxideReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by SLC25A2, GATM, NOS3, NOS1 and 1 moreinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• CHEBI:16523Reach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by SLC25A2, GATM, SLC3A2, SLC7A10inner side of the membrane, outer side of the membrane, cytosol, extracellular spaceOne of 4 routes

• protein polypeptide chainReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. PROTEIN_BS

  Catalysed by SLC25A2, GATMinner side of the membrane, outer side of the membrane, cytosolOne of 17 routes

• 2-phenylacetamideReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by SLC25A2, SLC7A6, EPXinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• CHEBI:16633Reach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC25A2, SLC7A6, SCLYinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Met-tRNA(Met)Reach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by SLC25A2, SLC7A6, MARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by SLC25A2, SLC7A6, AADATinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by SLC25A2, SLC7A6, CNDP2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 2-oxobutanoateReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of ornithine and threonine (cytosol to extracellular)
  3. L-threonine ammonia-lyase (2-oxobutanoate-forming)

  Catalysed by SLC25A2, SLC7A6, SDS, SDSLinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• tryptamineReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-tryptophan decarboxy-lyase

  Catalysed by SLC25A2, SLC7A6, DDCinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 2-oxoglutaramateReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by SLC25A2, SLC7A6, KYAT1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• CHEBI:16856Reach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by SLC25A2, GATM, GSSinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• glyoxylic acidReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC25A2, GATM, DAOinner side of the membrane, outer side of the membrane, cytosol, peroxisome

• CHEBI:17380Reach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by SLC25A2, SLC7A6, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. L-Ornithine:2-oxo-acid aminotransferase
  3. aldehyde dehydrogenase (1-pyrroline-5-carboxylate)

  Catalysed by SLC25A2, OAT, ALDH4A1inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 4 routes

• agmatineReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by SLC25A2, GATMinner side of the membrane, outer side of the membrane, cytosol, mitochondrial matrix

• AH2Reach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by SLC25A2, SLC7A6, MOCOSinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• S-methyl-5'-thioadenosineReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. L-ornithine carboxy-lyase (putrescine-forming)
  3. S-adenosylmethioninamine:putrescine 3-aminopropyltransferase

  Catalysed by SLC25A2, ODC1, SRMinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• 5-aminolevulinic acidReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by SLC25A2, GATM, ALAS1, ALAS2 and 1 moreinner side of the membrane, outer side of the membrane, cytosol, mitochondrial matrix

• indole-3-pyruvateReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by SLC25A2, SLC7A6, IL4I1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• Ala-tRNA(Ala)Reach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC25A2, SLC7A6, AARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• CHEBI:17769Reach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. L-ornithine carboxy-lyase (putrescine-forming)
  3. Putrescine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC25A2, ODC1, AOC2, AOC1 and 1 moreinner side of the membrane, outer side of the membrane, cytosol, extracellular spaceOne of 2 routes

• trans-urocanateReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of histidine and ornithine (cytosol to extracellular)
  3. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by SLC25A2, SLC7A5, SLC7A6, HALinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 5-hydroxy-L-tryptophanReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by SLC25A2, SLC7A6, TPH1, TPH2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 4-methyl-2-oxopentanoateReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of leucine and ornithine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC25A2, SLC7A6, BCAT2inner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrixOne of 4 routes

• CHEBI:17927Reach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. Transport by Y+Lat-2 into Extracellular Space

  Catalysed by SLC25A2, GATM, SLC3A2, SLC7A6inner side of the membrane, outer side of the membrane, cytosol, extracellular space

• 3-phenylpyruvateReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. Phenylalanine Transaminase, Mitochondrial

  Catalysed by SLC25A2, SLC7A6, GOT2, TATinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrixOne of 5 routes

• CHEBI:18095Reach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. Transport of Hydroxy-Proline

  Catalysed by SLC25A2, SLC7A6, SLC1A4inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by SLC25A2, GATM, GARTinner side of the membrane, outer side of the membrane, cytosol