malonic acid

Three steps

• 3-hydroxypyruvic acidReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. L-Serine:pyruvate aminotransferase

  Catalysed by SLC25A10, MPST, TST, AGXTmitochondrial matrix, cytosolOne of 2 routes

• (indol-3-yl)acetateReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. (indol-3-yl)acetate(out) + a dicarboxylate(in) = (indol-3-yl)acetate(in) + a dicarboxylate(out)

  Catalysed by SLC25A10, SLC25A35, SLC25A34, SLC22A6 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• an alcoholReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by SLC25A10, TSTD1, CP, PRDX6mitochondrial matrix, cytosol

• isocitric acidReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SLC25A10, SLC25A1mitochondrial matrix, cytosolOne of 6 routes

• glutarateReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)

  Catalysed by SLC25A10, STS, SLC22A24, SLC22A8mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• pentanoateReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. pentanoate(out) + dehydroepiandrosterone 3-sulfate(in) = pentanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by SLC25A10, STS, SLC22A9mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• (9Z)-hexadecenoateReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 6 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• L-lysineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)

  Catalysed by SLC6A14, SLC7A9, SLC25A29, SLC7A6extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• putrescineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of arginine and chloride (cytosol to extracellular)
  3. Putrescine Export via Putrescine/Arginine Antiporter

  Catalysed by SLC6A14, SLC3A2, SLC7A7extracellular space, cytosol

• cis-aconitic acidReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SLC25A10, SLC25A1mitochondrial matrix, cytosolOne of 6 routes

• N-carbamoyl-L-aspartateReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by SLC25A10, SLC25A14, SLC25A30, CADmitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• 3-oxopropanoateReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by SLC25A10, MPST, TST, AGXT2mitochondrial matrix, cytosolOne of 2 routes

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and methionine (cytosol to extracellular)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC6A14, IL4I1extracellular space, cytosol

• di-mu-sulfido-diiron(2+)Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. De novo synthesis of 2Fe2S

  Catalysed by SLC6A14, NDUFAB1, FDXR, FXN and 4 moreextracellular space, cytosol, mitochondrial matrix

• a phenolReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. an aryl sulfate + H2O = a phenol + sulfate + H(+)
  3. an aryl sulfate + H2O = a phenol + sulfate + H(+)

  Catalysed by SLC25A10, ARSL, ARSF, ARSK and 3 moremitochondrial matrix, cytosol

• serotoninReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride (cytosol to extracellular)
  3. transport of serotonin (cytosol to extracellular)

  Catalysed by SLC12A2, SLC12A1, SLC6A4extracellular space, cytosol

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and isoleucine (cytosol to extracellular)
  3. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by SLC6A14, BCAT2, BCAT1extracellular space, cytosol

• D-cysteineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of alanine and chloride (cytosol to extracellular)
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by SLC6A14, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. D-serine = pyruvate + NH4(+)

  Catalysed by SLC25A10, MPST, TST, SRRmitochondrial matrix, cytosolOne of 11 routes

• an acylcholineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and choline (cytosol to extracellular)
  3. an acylcholine + H2O = a carboxylate + choline + H(+)

  Catalysed by SLC5A7, BCHEextracellular space, cytosol

• 5-aminolevulinateReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and glycine (cytosol to extracellular)
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by SLC6A9, SLC6A14, ALAS1, ALAS2extracellular space, cytosol

• 3-methyl-2-oxovaleric acidReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and isoleucine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC6A14, BCAT1extracellular space, cytosolOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of L-Tyrosine by Atb0 Transporter
  3. L-tyrosine:2-oxoglutarate aminotransferase

  Catalysed by SLC6A14, GOT2, GOT1, TATextracellular space, cytosolOne of 3 routes

• glycochenodeoxycholateReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by SLC25A10, TSTD1, ABCC4mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• taurocholateReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. taurocholate(in) + glutathione(in) + ATP + H2O = taurocholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by SLC25A10, TSTD1, ABCC4mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• taurodeoxycholateReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by SLC6A6, BAATextracellular space, cytosolOne of 2 routes

• glycochenodeoxycholic acidReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and glycine (cytosol to extracellular)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SLC6A9, SLC6A14, BAATextracellular space, cytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)

  Catalysed by SLC25A10, CLYBLmitochondrial matrix, cytosolOne of 12 routes

• glycolithocholic acidReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and glycine (cytosol to extracellular)
  3. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by SLC6A9, SLC6A14, BAATextracellular space, cytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and glycine (cytosol to extracellular)
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by SLC6A9, SLC6A14, GCATextracellular space, cytosol, mitochondrial matrix

• (R)-lactic acidReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by SLC25A10, MPST, TST, LDHDmitochondrial matrix, cytosol

• (S)-lactic acidReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. (S)-Lactate:NAD+ oxidoreductase

  Catalysed by SLC25A10, MPST, TST, LDHB and 1 moremitochondrial matrix, cytosolOne of 7 routes

• L-erythro-7,8-dihydrobiopterinReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-erythro-7,8-dihydrobiopterin(out) + a dicarboxylate(in) = L-erythro-7,8-dihydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by SLC25A10, SLC25A35, SLC25A34, SLC22A6 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 2-iminopropanoateReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by SLC25A10, MPST, TST, RIDAmitochondrial matrix, cytosol

• phosphoenolpyruvic acidReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. pyruvate kinase (dTDP)

  Catalysed by SLC25A10, MPST, TST, PKM and 1 moremitochondrial matrix, cytosol

• N-acetyl-beta-neuraminic acidReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by SLC25A10, MPST, TST, NPLmitochondrial matrix, cytosol

• tert-butanolReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

  Catalysed by SLC25A10, TSTD1, CLIC2, GPX1 and 3 moremitochondrial matrix, cytosol

• L-ornithineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. taurine + L-arginine = taurocyamine + L-ornithine

  Catalysed by SLC6A6, GATMextracellular space, cytosolOne of 59 routes

• (5-hydroxyindol-3-yl)acetaldehydeReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. Transport of 5-Hydroxyindoleacetate
  3. (5-hydroxyindol-3-yl)acetaldehyde + NAD(+) + H2O = (5-hydroxyindol-3-yl)acetate + NADH + 2 H(+)

  Catalysed by SLC25A10, SLC4A1, ALDH9A1mitochondrial matrix, cytosol, extracellular space

• gamma-Glu-AlaReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of alanine and chloride (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by SLC6A14, GGT1, GGT5, GGTLC2 and 3 moreextracellular space, cytosol

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and glycine (cytosol to extracellular)
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by SLC6A9, SLC6A14, GLDC, GCSHextracellular space, cytosol, mitochondrial matrix

• 3,3',5-triiodo-L-thyronineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and iodide (cytosol to extracellular)
  3. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)

  Catalysed by SLC26A4, DIO1, DIO3, DIO2extracellular space, cytosolOne of 4 routes

• a 3-acylpyruvateReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by SLC25A10, MPST, TST, FAHD1mitochondrial matrix, cytosol

• (S)-malyl-CoAReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate

  Catalysed by SLC25A10, SUCLG1, SUCLA2mitochondrial matrix, cytosol

• butanoyl-CoAReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Carnitine Transport by Atb0
  3. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)

  Catalysed by SLC6A14, SLC33A1, ESCO2, OXSMextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• prostaglandin F2alphaReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)

  Catalysed by SLC25A10, SLC25A35, SLC25A34, SLC22A6mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by SLC25A10, TSTD1, GPX1, GPX2 and 1 moremitochondrial matrix, cytosol

• D-alanineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of alanine and chloride (cytosol to extracellular)
  3. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

  Catalysed by SLC6A14, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• sarcosineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and glycine (cytosol to extracellular)
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by SLC6A9, SLC6A14, PIPOXextracellular space, cytosolOne of 2 routes