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Proteins/UNIPROT:Q92813
Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination. Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (3,3'-T2) and 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via outer-ring deiodination (ORD). Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine and 3',5'- diiodothyronamine..
Function from UniProtKB (Q92813), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
62 statements
62 statements · 7 reference databases · Subject: DIO2 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
15 reactions
3,3'-diiodo-L-thyronine+iodide+NADP(3-)NADPH(4-)+3,3',5-triiodo-L-thyronine
Catalysed by DIO3 or DIO2 or DIO1
Reaction pageReversibleBalancedEC 1.21.99.4, 1.21.99.3cytosol
Human-GEM MAR06826CC BY 4.0Reference data
6 names
Resolves to: DIO2
Reaction pageReversibleBalancedEC 1.21.99.4, 1.21.99.3endoplasmic reticulum
Human-GEM MAR06827CC BY 4.0Reference data
3,3'-diiodo-L-thyronine+iodide+NADP(3-)NADPH(4-)+MAM02839c
Reaction pageReversibleBalancedEC 1.21.99.4cytosol
Human-GEM MAR06834CC BY 4.0Reference data
3,3'-diiodo-L-thyronine+iodide+NADP(3-)NADPH(4-)+MAM02839r
Reaction pageReversibleBalancedEC 1.21.99.4endoplasmic reticulum
Human-GEM MAR06835CC BY 4.0Reference data
MAM00736c+iodide+NADP(3-)NADPH(4-)+3,3',5-triiodo-L-thyronine
Reaction pageReversibleBalancedEC 1.21.99.4cytosol
Human-GEM MAR06840CC BY 4.0Reference data
MAM00736r+iodide+NADP(3-)NADPH(4-)+3,3',5-triiodo-L-thyronine
Reaction pageReversibleBalancedEC 1.21.99.4endoplasmic reticulum
Human-GEM MAR06841CC BY 4.0Reference data
MAM00736c+NADPH(4-)MAM00828c+iodide+NADP(3-)
Reaction pageReversibleBalancedEC 1.21.99.4cytosol
Human-GEM MAR06848CC BY 4.0Reference data
MAM00736r+NADPH(4-)MAM00828r+iodide+NADP(3-)
Reaction pageReversibleBalancedEC 1.21.99.4endoplasmic reticulum
Human-GEM MAR06849CC BY 4.0Reference data
iodide+NADP(3-)+3,3',5-triiodo-L-thyronineNADPH(4-)+L-thyroxine
Reaction pageReversibleBalancedEC 1.21.99.4cytosol
Human-GEM MAR06854CC BY 4.0Reference data
iodide+NADP(3-)+3,3',5-triiodo-L-thyronineNADPH(4-)+L-thyroxine
Reaction pageReversibleBalancedEC 1.21.99.4endoplasmic reticulum
Human-GEM MAR06855CC BY 4.0Reference data
3,3',5-triiodo-L-thyronine+iodide+A+hydronL-thyroxine+AH2
Reaction pageRight to leftBalanced
Rhea RHEA:19745CC BY 4.0Reference data
3,3'-diiodo-L-thyronine+iodide+A+hydron3,3',5'-triiodo-L-thyronine+AH2
Reaction pageRight to leftBalanced
Rhea RHEA:82575CC BY 4.0Reference data