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Proteins/UNIPROT:P23378
The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH)..
Function from UniProtKB (P23378), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
5 rows
68 statements
68 statements · 8 reference databases · Subject: GLDC · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
2 reactions
MAM00209m+glycine+protoncarbon dioxide+S(8)-aminomethyldihydrolipoamide
Reaction pageLeft to rightUnbalancedEC 1.8.1.4, 2.1.2.10mitochondrial matrix
Human-GEM MAR08433CC BY 4.0Reference data
N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein]+glycine+hydronN(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein]+carbon dioxide
5 names
Resolves to: GLDC
Catalysed by GLDC
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:24304CC BY 4.0Reference data