formic acid

Three steps

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by SLC26A4, SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• acetaldehydeReach from here →
  1. transport of acetate and formate (cytosol to extracellular)
  2. cytochrome P450 (17alpha-hydroxypregnenolone)
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by SLC16A4, SLC16A5, SLC16A1, CYP17A1extracellular space, cytosol, endoplasmic reticulumOne of 4 routes

• acetylcholineReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by SLC26A4, SLC5A7, CHATextracellular space, cytosolOne of 3 routes

• 4a-hydroxytetrahydrobiopterinReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase(4-hydroxylating)

  Catalysed by SLC26A4, SLC6A14, PAHextracellular space, cytosolOne of 3 routes

• CHEBI:15467Reach from here →
  1. transport of acetoacetate and formate (cytosol to extracellular)
  2. Acetoacetate:CoA ligase (AMP-forming)
  3. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)

  Catalysed by SLC16A4, SLC16A5, AACS, HMGCS1extracellular space, cytosolOne of 3 routes

• CHEBI:15477Reach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. 2-Methylbutyrylglycine Transport, Extracellular
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by SLC26A4, SLC6A5, GLYAT, GLYATL2 and 1 moreextracellular space, cytosol, mitochondrial matrix

• CHEBI:15570Reach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. alanine racemase

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 moreextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• CHEBI:15611Reach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by SLC26A4, SLC6A9, SLC6A14, GNMTextracellular space, cytosol

• (6R)-5,10-methylene-5,6,7,8-tetrahydrofolateReach from here →
  1. Formate:tetrahydrofolate ligase (ADP-forming)
  2. 5,10-Methenyltetrahydrofolate 5-hydrolase (decyclizing)
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methenyltetrahydrofolate + NADH

  Catalysed by MTHFD1, MTHFD2, MTHFD2Lcytosol

• 5-methyltetrahydrofolic acidReach from here →
  1. Formate:tetrahydrofolate ligase (ADP-forming)
  2. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  3. histamine N-methyltransferase (SAM)

  Catalysed by MTHFD1, ALDH1L1, ALDH1L2, HNMTcytosol

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine

  Catalysed by SLC26A4, SLC6A14, PAHextracellular space, cytosolOne of 2 routes

• CHEBI:15699Reach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and homoserine (cytosol to extracellular)

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 3 moreextracellular space, cytosol, mitochondrial matrixOne of 52 routes

• betaine aldehydeReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of chloride and choline (cytosol to extracellular)
  3. choline dehydrogenase (choline)

  Catalysed by SLC26A4, SLC5A7, CHDHextracellular space, cytosolOne of 3 routes

• trimethylenediamineReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of chloride and lysine (cytosol to extracellular)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by SLC26A4, SLC6A14, DHPSextracellular space, cytosol

• CHEBI:15727Reach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of chloride and histidine (cytosol to extracellular)
  3. L-histidine:beta-alanine ligase (ADP-forming)

  Catalysed by SLC26A4, SLC6A14, CARNS1extracellular space, cytosolOne of 2 routes

• hexadecanoic acidReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC26A4, SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• CHEBI:15765Reach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. Transport of L-Tyrosine by Atb0 Transporter
  3. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by SLC26A4, SLC6A14, THextracellular space, cytosolOne of 5 routes

• malonateReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 3 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• (R)-2-hydroxyglutarateReach from here →
  1. transport of acetoacetate and formate (cytosol to extracellular)
  2. (S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate
  3. AKG[m] + (S)-3-hydroxybutanoate[m] = acetoacetate[m] + (R)-2-hydroxyglutarate[m]

  Catalysed by SLC16A4, SLC16A5, ADHFE1extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• alpha-D-glucosamine 6-phosphateReach from here →
  1. transport of acetate and formate (cytosol to extracellular)
  2. N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate
  3. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase

  Catalysed by SLC16A4, SLC16A5, SLC16A1, AMDHD2 and 1 moreextracellular space, cytosolOne of 2 routes

• ferricytochrome cReach from here →
  1. transport of formate and L-lactate (cytosol to extracellular)
  2. (S)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol, mitochondrial matrixOne of 4 routes

• 11-cis-retinalReach from here →
  1. transport of formate and retinoate (cytosol to extracellular)
  2. retinoate reduction
  3. all-trans-Retinal 11-cis-trans-isomerase

  Catalysed by SLC16A4, SLC16A5, RBP1, RBP2extracellular space, cytosol

• CHEBI:16174Reach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. pyruvate kinase (dTDP)
  3. nucleoside-diphosphate kinase (dADP)

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 9 moreextracellular space, cytosolOne of 3 routes

• ureaReach from here →
  1. transport of formate and L-lactate (cytosol to extracellular)
  2. transport of L-lactate and urate (cytosol to extracellular)
  3. Peroxidase

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 4 moreextracellular space, cytosol, nucleusOne of 6 routes

• succinic semialdehydeReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
  3. 4-aminobutanoate:2-oxoglutarate aminotransferase

  Catalysed by SLC26A4, SLC6A12, ABATextracellular space, cytosol, mitochondrial matrix

• L-cystineReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 4 moreextracellular space, cytosol, mitochondrial matrixOne of 7 routes

• CHEBI:16284Reach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. pyruvate kinase (dTDP)
  3. deoxythymidylate kinase (dADP)

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 4 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. (S)-3-amino-2-methylpropionate transaminase (2-methyl-3-oxopropanoate)

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 3 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• (R)-carnitineReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of betaine and chloride (cytosol to extracellular)
  3. glycine betaine(out) + (R)-carnitine(in) = glycine betaine(in) + (R)-carnitine(out)

  Catalysed by SLC26A4, SLC6A12, SLC22A5extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-citrullineReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and citrulline (cytosol to extracellular)

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 3 moreextracellular space, cytosol, mitochondrial matrixOne of 39 routes

• (17R,20S)-17,20-dihydroxypregn-4-en-3-oneReach from here →
  1. transport of acetate and formate (cytosol to extracellular)
  2. cytochrome P450 (17alpha-hydroxyprogesterone)
  3. (17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) = 17alpha-hydroxyprogesterone + NADH + H(+)

  Catalysed by SLC16A4, SLC16A5, SLC16A1, CYP17A1 and 1 moreextracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• androst-4-ene-3,17-dioneReach from here →
  1. transport of acetate and formate (cytosol to extracellular)
  2. cytochrome P450 (17alpha-hydroxyprogesterone)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by SLC16A4, SLC16A5, SLC16A1, CYP17A1extracellular space, cytosol, endoplasmic reticulumOne of 5 routes

• nitric oxideReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by SLC26A4, SLC6A14, NOS3, NOS1 and 1 moreextracellular space, cytosolOne of 2 routes

• CHEBI:16497Reach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. pyruvate kinase (dTDP)
  3. dGTP:pyruvate 2-O-phosphotransferase

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 3 moreextracellular space, cytosol

• CHEBI:16523Reach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by SLC26A4, SLC6A9, SLC6A14, SLC3A2 and 1 moreextracellular space, cytosolOne of 4 routes

• protein polypeptide chainReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. PROTEIN_BS

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 moreextracellular space, cytosol, mitochondrial matrixOne of 17 routes

• 2-phenylacetamideReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by SLC26A4, SLC6A14, EPXextracellular space, cytosol

• CHEBI:16633Reach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 3 moreextracellular space, cytosol, mitochondrial matrix

• Met-tRNA(Met)Reach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 4 moreextracellular space, cytosol

• (R)-glycerateReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. L-Serine:pyruvate aminotransferase
  3. D-glycerate:NADP+ 2-oxidoreductase

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 3 moreextracellular space, cytosolOne of 4 routes

• quinolinic acidReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of Quinolinic Acid

  Catalysed by SLC26A4, SLC26A6, SLC22A6extracellular space, cytosolOne of 2 routes

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 4 moreextracellular space, cytosol

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 7 moreextracellular space, cytosolOne of 2 routes

• tryptamineReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-tryptophan decarboxy-lyase

  Catalysed by SLC26A4, SLC6A14, DDCextracellular space, cytosol

• CHEBI:16856Reach from here →
  1. transport of formate and L-lactate (cytosol to extracellular)
  2. Transport of Prostaglandin A2, Lactate Antiport
  3. transport of GSH and prostaglandin A2 (cytosol to extracellular)

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosolOne of 6 routes

• glyoxylic acidReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC26A4, SLC6A9, SLC6A14, DAOextracellular space, cytosol, peroxisome

• creatineReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. Transport of Guanidinoacetic Acid
  3. S-Adenosyl-L-methionine:guanidinoacetate N-methyltransferase

  Catalysed by SLC26A4, GAMTextracellular space, cytosolOne of 2 routes

• glycolaldehydeReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. L-Serine:pyruvate aminotransferase
  3. hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 moreextracellular space, cytosolOne of 2 routes

• 4-maleylacetoacetateReach from here →
  1. transport of acetoacetate and formate (cytosol to extracellular)
  2. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)
  3. 4-maleylacetoacetate = 4-fumarylacetoacetate

  Catalysed by SLC16A4, SLC16A5, FAH, GSTZ1extracellular space, cytosol

• aldehydo-N-acetyl-D-mannosamineReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 moreextracellular space, cytosolOne of 2 routes