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Proteins/UNIPROT:P13995
Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency..
Function from UniProtKB (P13995), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
788 statements
788 statements · 7 reference databases · Subject: MTHFD2 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways · Rows fetched: 300
6 reactions
ATP+formic acid+5,6,7,8-tetrahydrofolic acid10-formyltetrahydrofolic acid+ADP+phosphate(3-)
Catalysed by MTHFD2 or MTHFD1L or MTHFD2L
Reaction pageLeft to rightBalancedEC 3.5.4.9, 6.3.4.3mitochondrial matrix
Human-GEM MAR04340CC BY 4.0Reference data
(6R)-5,10-methenyltetrahydrofolate+NADH(2-)(6R)-5,10-methylenetetrahydrofolic acid
2 names
Resolves to: MTHFD2
Reaction pageReversibleBalancedEC 1.5.1.15mitochondrial matrix
Human-GEM MAR04440CC BY 4.0Reference data
(6R)-5,10-methenyltetrahydrofolate+NADPH(4-)(6R)-5,10-methylenetetrahydrofolic acid+NADP(3-)
Catalysed by MTHFD2 or MTHFD1 or MTHFD1L
Reaction pageReversibleBalancedEC 1.5.1.5mitochondrial matrix
Human-GEM MAR04444CC BY 4.0Reference data
10-formyltetrahydrofolic acid+proton(6R)-5,10-methenyltetrahydrofolate+water
Catalysed by MTHFD2 or MTHFD1L or MTHFD2L
Reaction pageReversibleBalancedEC 3.5.4.9mitochondrial matrix
Human-GEM MAR04505CC BY 4.0Reference data
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate+NAD(1-)(6R)-5,10-methenyltetrahydrofolate+NADH(2-)
Catalysed by MTHFD2 or MTHFD2L
Reaction pageDirection not assertedBalanced
Rhea RHEA:22892CC BY 4.0Reference data
(6R)-5,10-methenyltetrahydrofolate+water(6R)-10-formyltetrahydrofolate+hydron
Catalysed by MTHFD1 or MTHFD2 or MTHFD2L
Reaction pageDirection not assertedBalanced
Rhea RHEA:23700CC BY 4.0Reference data