Compound
CHEBI:15467
A 3-hydroxy-3-methylglutaryl-CoA where the 3-hydroxy-3-methylglutaryl component has (S)-configuration.
Definition from ChEBI (CHEBI:15467), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
4 entities
4 entities reached.
0 reported hops4 assembled from the scaffold
What the reference databases state
Statements
11 statements
11 statements · 1 reference database · Subject: CHEBI:15467 · Sources: Human-GEM
- CHEBI:15467 is converted to 3-methyl-(2E)-glutaconyl-CoACompoundHuman-GEM MAR03775Inferred only
- 3-methyl-(2E)-glutaconyl-CoA is converted to CHEBI:15467CompoundHuman-GEM MAR03775Inferred only
- CHEBI:15467 is converted to acetoacetateCompoundHuman-GEM MAR01449Inferred only
- CHEBI:15467 is converted to acetoacetateCompoundHuman-GEM MAR01577Inferred only
- CHEBI:15467 is a substrate of AUHProteinHuman-GEM MAR03775Inferred only
- CHEBI:15467 is a substrate of HMGCLProteinHuman-GEM MAR01577Inferred only
- CHEBI:15467 is a substrate of HMGCLProteinHuman-GEM MAR01449Inferred only
- CHEBI:15467 is a substrate of HMGCLL1ProteinHuman-GEM MAR01577Inferred only
- CHEBI:15467 is a substrate of HMGCRProteinHuman-GEM MAR01440Inferred only
- CHEBI:15467 is a substrate of HMGCRProteinHuman-GEM MAR01446Inferred only
- CHEBI:15467 is a substrate of HMGCRProteinHuman-GEM MAR04630Inferred only
Reactions
12 reactions
CHEBI:15345+CHEBI:15351+waterCHEBI:1146900+proton+CHEBI:15467
Catalysed by HMGCS1
Reaction pageLeft to rightBalancedEC 2.3.3.10GO:0005829
Human-GEM MAR01437CC BY 4.0Reference data
2proton+CHEBI:15467+2NADPH(4-)MAM00167c+CHEBI:1146900+2NADP(3-)
Catalysed by HMGCR
Reaction pageLeft to rightBalancedEC 1.1.1.34GO:0005829
Human-GEM MAR01440CC BY 4.0Reference data
2proton+CHEBI:15467+2NADPH(4-)MAM00167r+CHEBI:1146900+2NADP(3-)
Catalysed by HMGCR
Reaction pageLeft to rightBalancedEC 1.1.1.88GO:0005783
Human-GEM MAR01446CC BY 4.0Reference data
Reaction pageReversibleBalancedGO:0005829, GO:0005777
Human-GEM MAR01447CC BY 4.0Reference data
CHEBI:15467acetoacetate+CHEBI:15351
Catalysed by HMGCL
Reaction pageLeft to rightBalancedEC 4.1.3.4GO:0005777
Human-GEM MAR01449CC BY 4.0Reference data
Reaction pageReversibleBalancedGO:0005829, GO:0005759
Human-GEM MAR01572CC BY 4.0Reference data
CHEBI:15345+CHEBI:15351+waterCHEBI:1146900+proton+CHEBI:15467
Catalysed by HMGCS2
Reaction pageLeft to rightBalancedEC 2.3.3.10GO:0005759
Human-GEM MAR01573CC BY 4.0Reference data
CHEBI:15467acetoacetate+CHEBI:15351
Reaction pageLeft to rightBalancedEC 4.1.3.4GO:0005759
Human-GEM MAR01577CC BY 4.0Reference data
3-methyl-(2E)-glutaconyl-CoA+waterCHEBI:15467
Catalysed by AUH
Reaction pageReversibleBalancedEC 4.2.1.18GO:0005759
Human-GEM MAR03775CC BY 4.0Reference data
CHEBI:15345+CHEBI:15351+waterCHEBI:1146900+proton+CHEBI:15467
Reaction pageLeft to rightBalancedEC 2.3.3.10GO:0005777
Human-GEM MAR04604CC BY 4.0Reference data
2proton+CHEBI:15467+2NADPH(4-)MAM00167x+CHEBI:1146900+2NADP(3-)
Catalysed by HMGCR
Reaction pageLeft to rightBalancedEC 1.1.1.34GO:0005777
Human-GEM MAR04630CC BY 4.0Reference data
water+CHEBI:15467CHEBI:1146900+proton+3-hydroxy-3-methylglutarate
Reaction pageLeft to rightBalancedGO:0005829
Human-GEM MAR11492CC BY 4.0Reference data
Other names
9 names
Resolves to: CHEBI:15467
- Also called
- (3S)-3-hydroxy-3-methylglutaryl-coenzyme A(S)-3-Hydroxy-3-methylglutaryl-CoA(S)-3-hydroxy-3-methylglutaryl-coenzyme A3-Hydroxy-3-methylglutaryl-CoAHMG-CoAHMG-coenzyme AHydroxymethylglutaroyl coenzyme AHydroxymethylglutaryl-CoA
- Systematic name
- 3'-phosphoadenosine 5'-{3-[(3R)-4-({3-[(2-{[(3S)-4-carboxy-3-hydroxy-3-methylbutanoyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)-3-hydroxy-2,2-dimethyl-4-oxobutyl] dihydrogen diphosphate}