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Proteins/UNIPROT:O95907
Probable retinal pigment epithelium (RPE)-specific proton-coupled L-lactate transporter (By similarity). May facilitate transport of lactate and H(+) out of the retina and could therefore play a role in pH and ion homeostasis of the outer retina (By similarity)..
Function from UniProtKB (O95907), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
80 statements
80 statements · 5 reference databases · Subject: SLC16A8 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea
35 reactions
(R)-lactic acid+proton(R)-lactic acid+proton
Transported by SLC16A8 or SLC16A6 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR03858CC BY 4.0Reference data
3 names
Resolves to: SLC16A8
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR04928CC BY 4.0Reference data
proton+pyruvateproton+pyruvate
Transported by SLC16A8 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, peroxisome
Human-GEM MAR04930CC BY 4.0Reference data
Transported by SLC16A8 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR04935CC BY 4.0Reference data
acetoacetate+protonacetoacetate+proton
Transported by SLC16A8 or SLC16A6 or SLC16A7 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR04976CC BY 4.0Reference data
2-oxobutanoate+proton2-oxobutanoate+proton
Transported by SLC16A8 or SLC16A6 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR05348CC BY 4.0Reference data
2-oxobutanoate+proton2-oxobutanoate+proton
Transported by SLC16A8 or SLC16A6 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageLeft to rightBalancedmitochondrial matrix, mitochondrial intermembrane space, cytosol
Human-GEM MAR05349CC BY 4.0Reference data
proton+(S)-lactic acidproton+(S)-lactic acid
Transported by SLC16A8 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR05998CC BY 4.0Reference data
acetoacetate+propionic acidacetoacetate+propionic acid
Transported by SLC16A8 or SLC16A7 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06003CC BY 4.0Reference data
acetoacetate+(S)-lactic acidacetoacetate+(S)-lactic acid
Transported by SLC16A8 or SLC16A7 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR06004CC BY 4.0Reference data
2-hydroxybutyric acid+pyruvate2-hydroxybutyric acid+pyruvate
Transported by SLC16A8 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06007CC BY 4.0Reference data
2-hydroxybutyric acid+(S)-lactic acid2-hydroxybutyric acid+(S)-lactic acid
Transported by SLC16A8 or SLC16A6 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06011CC BY 4.0Reference data