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Proteins/UNIPROT:O75891
Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide. May also have an NADP(+)-dependent aldehyde dehydrogenase activity towards formaldehyde, acetaldehyde, propionaldehyde, and benzaldehyde (By similarity)..
Function from UniProtKB (O75891), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
31 statements
31 statements · 6 reference databases · Subject: ALDH1L1 · Sources: Bgee, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
3 reactions
10-formyltetrahydrofolic acid+water+NADP(3-)carbon dioxide+proton+NADPH(4-)+5,6,7,8-tetrahydrofolic acid
Catalysed by ALDH1L2 or ALDH1L1
Reaction pageLeft to rightBalancedEC 1.5.1.6cytosol
Human-GEM MAR04336CC BY 4.0Reference data
4 names
Resolves to: ALDH1L1
Reaction pageLeft to rightBalancedEC 1.5.1.6cytosol
Human-GEM MAR08758CC BY 4.0Reference data
(6R)-10-formyltetrahydrofolate+NADP(3-)+water(6S)-5,6,7,8-tetrahydrofolate+carbon dioxide+NADPH(4-)+hydron
Catalysed by ALDH1L1 or ALDH1L2
Reaction pageLeft to rightBalanced
Rhea RHEA:10180CC BY 4.0Reference data