Compound

(R)-2-hydroxyglutarate

A 2-hydroxyglutarate(2−) that has (2R)-configuration.

Definition from ChEBI (CHEBI:15801), read 2026-09-23. CC BY 4.0.

CHEBI:15801ChEBI

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Structure

2D depiction · 3D model shown

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A generated conformer of (R)-2-hydroxyglutarate — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound, anion
Formula: C5H6O5
Mass: 146.098 g/mol
Charge: -2
InChIKey: HWXBTNAVRSUOJR-GSVOUGTGSA-L
SMILES: O=C([O-])CC[C@@H](O)C(=O)[O-]
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

3 entities

3 entities reached.

0 reported hops3 assembled from the scaffold

What the reference databases state

Chemical structure

(R)-2-hydroxyglutarate is the enantiomer of (S)-2-hydroxyglutarateCompoundChEBI CHEBI:15801Inferred only

Statements

4 statements

4 statements · 1 reference database · Subject: (R)-2-hydroxyglutarate · Sources: Rhea

Order

(R)-2-hydroxyglutarate is a substrate of ADHFE1ProteinRhea RHEA:23048Inferred only
(R)-2-hydroxyglutarate is a substrate of ADHFE1ProteinRhea RHEA:24734Inferred only
(R)-2-hydroxyglutarate is a substrate of D2HGDHProteinRhea RHEA:38295Inferred only
(R)-2-hydroxyglutarate is a substrate of PHGDHProteinRhea RHEA:49612Inferred only

Reactions

11 reactions

2-oxoglutarate(2-)+(S)-3-hydroxybutanoateacetoacetate+(R)-2-hydroxyglutarate
Catalysed by ADHFE1
Reaction pageLeft to rightBalancedEC 1.1.99.24GO:0005759
Human-GEM MAR20013CC BY 4.0Reference data
(S)-3-hydroxybutanoate+2-oxoglutarate(2-)(R)-2-hydroxyglutarate+acetoacetate
Catalysed by ADHFE1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:23048CC BY 4.0Reference data
4-hydroxybutanoate+2-oxoglutarate(2-)(R)-2-hydroxyglutarate+succinate semialdehyde
Catalysed by ADHFE1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:24734CC BY 4.0Reference data
(R)-2-hydroxyglutarate+A2-oxoglutarate(2-)+AH2
Catalysed by D2HGDH
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:38295CC BY 4.0Reference data
(R)-2-hydroxyglutarate+NAD(1-)2-oxoglutarate(2-)+NADH(2-)+hydron
Catalysed by PHGDH
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:49612CC BY 4.0Reference data
(R)-2-hydroxyglutarate+NADP(3-)2-oxoglutarate(2-)+NADPH(4-)+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:51192CC BY 4.0Reference data
(R)-2-hydroxyglutarate+pyruvate(R)-lactate+2-oxoglutarate(2-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:51608CC BY 4.0Reference data
(R)-2-hydroxyglutarate+oxaloacetate(R)-malate+2-oxoglutarate(2-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:51612CC BY 4.0Reference data
(R)-2-hydroxyglutarate+FAD(3-)+hydronFADH2(2-)+2-oxoglutarate(2-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:57168CC BY 4.0Reference data
2-oxoadipate+dioxygen(R)-2-hydroxyglutarate+carbon dioxide
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:71787CC BY 4.0Reference data
(R)-2-hydroxyglutarate+3sodium(1+)(R)-2-hydroxyglutarate+3sodium(1+)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:71963CC BY 4.0Reference data

Other names

1 name

Resolves to: (R)-2-hydroxyglutarate

Systematic name: (2R)-2-hydroxypentanedioate