Compound
quinolinic acid
A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have aids.
What it touches on the way
Mechanistic reach
2 entities
2 entities reached.
0 reported hops2 assembled from the scaffold
What the reference databases state
Statements
3 statements
3 statements · 1 reference database · Subject: quinolinic acid · Sources: Human-GEM
- (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde is converted to quinolinic acidCompoundHuman-GEM MAR04250Inferred only
- quinolinic acid is a substrate of QPRTProteinHuman-GEM MAR04251Inferred only
- quinolinic acid is transported by SLC22A6ProteinHuman-GEM MAR09819Inferred only
Reactions
4 reactions
(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehydeproton+water+quinolinic acid
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR04250CC BY 4.0Reference data
2proton+5-phospho-alpha-D-ribose 1-diphosphate+quinolinic acidcarbon dioxide+nicotinic acid D-ribonucleotide+diphosphate(3-)
Catalysed by QPRT
Reaction pageLeft to rightBalancedEC 2.4.2.19cytosol
Human-GEM MAR04251CC BY 4.0Reference data
quinolinic acid+sulfatequinolinic acid+sulfate
Transported by SLC22A6
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR09819CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR09859CC BY 4.0Reference data
Other names
3 names
Resolves to: quinolinic acid
- Also called
- 2,3-Pyridinedicarboxylic acidPyridine-2,3-dicarboxylate
- Systematic name
- pyridine-2,3-dicarboxylic acid