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Proteins/UNIPROT:Q8IWW8
Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities..
Function from UniProtKB (Q8IWW8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
30 statements
30 statements · 7 reference databases · Subject: ADHFE1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
15 reactions
3 names
Resolves to: ADHFE1
Reaction pageReversibleBalancedEC 1.1.1.1mitochondrial matrix
Human-GEM MAR01130CC BY 4.0Reference data
MAM00596x+NAD(+)MAM00601x+proton+NADH(2-)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedEC 1.1.1.1peroxisome
Human-GEM MAR01288CC BY 4.0Reference data
MAM00756c+proton+NADH(2-)MAM01093c+NAD(+)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageReversibleBalancedEC 1.1.1.1cytosol
Human-GEM MAR01684CC BY 4.0Reference data
MAM01110m+NADP(3-)(5-hydroxyindol-3-yl)acetaldehyde+proton+NADPH(4-)
Catalysed by ADHFE1
Reaction pageReversibleBalancedEC 1.1.1.1mitochondrial matrix
Human-GEM MAR02858CC BY 4.0Reference data
methanol+NAD(+)formaldehyde+proton+NADH(2-)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedEC 1.1.1.244cytosol
Human-GEM MAR04202CC BY 4.0Reference data
(5-hydroxyindol-3-yl)acetaldehyde+proton+NADPH(4-)MAM01110c+NADP(3-)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageReversibleBalancedEC 1.1.1.1cytosol
Human-GEM MAR04561CC BY 4.0Reference data
MAM00726c+proton+NADH(2-)MAM00730c+NAD(+)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH5 or ADH4 or ADH1C
Reaction pageReversibleBalancedEC 1.1.1.1cytosol
Human-GEM MAR06756CC BY 4.0Reference data
(R)-S-lactoylglutathione+proton+NADH(2-)(R)-lactaldehyde+CHEBI:16856+NAD(+)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH5 or ADH4 or ADH1C
Reaction pageReversibleBalancedEC 1.1.1.1cytosol
Human-GEM MAR08502CC BY 4.0Reference data
NAD(+)+propane-1,2-diol(R)-lactaldehyde+proton+NADH(2-)
Catalysed by ADHFE1 or ADH6 or PTGR3 or ADH1A or ADH7 or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR08507CC BY 4.0Reference data
NAD(+)+propane-1,2-diolproton+MAM02329c+NADH(2-)
Catalysed by ADHFE1 or ADH6 or PTGR3 or ADH1A or ADH7 or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR08508CC BY 4.0Reference data
formaldehyde+CHEBI:16856+NAD(+)S-formylglutathione+proton+NADH(2-)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH5 or ADH1C
Reaction pageReversibleBalancedEC 1.1.1.1cytosol
Human-GEM MAR08530CC BY 4.0Reference data