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Proteins/UNIPROT:Q01581
Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis..
Function from UniProtKB (Q01581), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
582 statements
582 statements · 6 reference databases · Subject: HMGCS1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
2 reactions
CHEBI:15345+CHEBI:15351+waterCHEBI:1146900+proton+CHEBI:15467
Catalysed by HMGCS1
Reaction pageLeft to rightBalancedEC 2.3.3.10cytosol
Human-GEM MAR01437CC BY 4.0Reference data
acetoacetyl-CoA+acetyl-CoA+water(3S)-3-hydroxy-3-methylglutaryl-CoA+coenzyme A(4-)
3 names
Resolves to: HMGCS1
Reaction pageLeft to rightBalanced
Rhea RHEA:10188CC BY 4.0Reference data