biocytin

Three steps

• L-cystine-bis-glycineReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glycine and lysine (cytosol to extracellular)
  3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by BTD, SLC7A6, DPEP1, DPEP2mitochondrial matrix, extracellular space, cytosol

• glycyldehydrophenylalanineReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glycine and lysine (cytosol to extracellular)
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by BTD, SLC7A6, DPEP1mitochondrial matrix, extracellular space, cytosol

• 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glutamine and lysine (cytosol to extracellular)
  3. N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)

  Catalysed by BTD, SLC7A6, PFASmitochondrial matrix, extracellular space, cytosol

• kinetensinReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of lysine and phenylalanine (cytosol to extracellular)
  3. Chymase

  Catalysed by BTD, SLC7A6, CMA1mitochondrial matrix, extracellular space, cytosolOne of 3 routes

• an N-(fatty acyl)-glycineReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glycine and lysine (cytosol to extracellular)
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by BTD, SLC7A6, GLYATL2mitochondrial matrix, extracellular space, cytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glycine and lysine (cytosol to extracellular)
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by BTD, SLC7A6, GLYATL2mitochondrial matrix, extracellular space, cytosol

• (7Z)-octadecenoyl-CoAReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)

  Catalysed by BTD, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 3 routes

• acetaldehydeReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of lysine and threonine (cytosol to extracellular)
  3. L-threonine acetaldehyde-lyase (glycine-forming)

  Catalysed by BTD, SLC7A6mitochondrial matrix, extracellular space, cytosol

• CHEBI:15345Reach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by BTD, AACSmitochondrial matrix, cytosolOne of 2 routes

• cholineReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of chloride and lysine (cytosol to extracellular)
  3. transport of chloride and choline (cytosol to extracellular)

  Catalysed by BTD, SLC6A14, SLC5A7mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• pyruvateReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of alanine and lysine (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by BTD, SLC7A6, AGXT2mitochondrial matrix, extracellular space, cytosolOne of 16 routes

• 4a-hydroxytetrahydrobiopterinReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of lysine and tryptophan (cytosol to extracellular)
  3. L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase(5-hydroxylating)

  Catalysed by BTD, SLC7A6, TPH1, TPH2mitochondrial matrix, extracellular space, cytosolOne of 3 routes

• CHEBI:15380Reach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by BTD, ALAS1, CPNE7mitochondrial matrixOne of 8 routes

• CHEBI:15477Reach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by BTD, GLYAT, GLYATL2, GLYATL1mitochondrial matrixOne of 2 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. Production of Tiglylcarnitine

  Catalysed by BTD, CPT1A, CPT1Bmitochondrial matrix, cytosolOne of 2 routes

• isobutyryl-CoAReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by BTD, HADHA, ACAA2, HADHBmitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by BTD, GLYATmitochondrial matrix

• isovaleryl-CoAReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by BTD, GLYAT, GLYATL2, GLYATL1mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by BTD, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 11 routes

• CHEBI:15519Reach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. propanoyl-CoA C-acyltransferase

  Catalysed by BTD, ACAA1, SCP2, MYO5Bmitochondrial matrix, peroxisomeOne of 2 routes

• palmitoyl-CoAReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by BTD, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 11 routes

• oleoyl-CoAReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by BTD, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 11 routes

• phenylacetyl-CoAReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. Phenylacetate:CoA ligase

  Catalysed by BTDmitochondrial matrix, cytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by BTD, ACSS3, ACSS2, ACSS1mitochondrial matrix, cytosolOne of 43 routes

• CHEBI:15570Reach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glycine and lysine (cytosol to extracellular)
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by BTD, SLC7A6, SLC3A2, SLC7A10mitochondrial matrix, extracellular space, cytosolOne of 5 routes

• CHEBI:15611Reach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glycine and lysine (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by BTD, SLC7A6, GNMTmitochondrial matrix, extracellular space, cytosol

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of lysine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by BTD, SLC7A6, TPH1, TPH2mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• CHEBI:15650Reach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by BTD, ZDHHC11B, NAA10, ESCO2 and 29 moremitochondrial matrix, cytosolOne of 2 routes

• CHEBI:15727Reach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of histidine and lysine (cytosol to extracellular)
  3. L-histidine:beta-alanine ligase (ADP-forming)

  Catalysed by BTD, SLC7A5, SLC7A6, CARNS1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• CHEBI:15746Reach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by BTD, SAT1, SAT2mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:15765Reach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of lysine and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by BTD, SLC7A6, THmitochondrial matrix, extracellular space, cytosolOne of 5 routes

• alpha-D-glucosamine 6-phosphateReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glutamine and lysine (cytosol to extracellular)
  3. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by BTD, SLC7A6, GFPT2, GFPT1mitochondrial matrix, extracellular space, cytosol

• sulfateReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of chloride and lysine (cytosol to extracellular)
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by BTD, SLC6A14, SLC26A6mitochondrial matrix, extracellular space, cytosol

• ureaReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of arginine and lysine (cytosol to extracellular)
  3. L-Arginine amidinohydrolase

  Catalysed by BTD, SLC3A2, SLC7A5, SLC7A6 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

• L-cystineReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of arginine and lysine (cytosol to extracellular)
  3. L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)

  Catalysed by BTD, SLC3A2, SLC7A5, SLC7A6 and 1 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 7 routes

• 11-cis-retinolReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by BTD, DGAT1, LRAT, AWAT1 and 2 moremitochondrial matrix, cytosol

• (R)-3-aminoisobutyric acidReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of alanine and lysine (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by BTD, SLC7A6, AGXT2mitochondrial matrix, extracellular space, cytosol

• iodideReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of lysine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by BTD, SLC7A6, TPOmitochondrial matrix, extracellular space, cytosolOne of 3 routes

• oxaloacetateReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. ATP citrate lyase (citrate)

  Catalysed by BTD, ACLYmitochondrial matrix, cytosol

• nitric oxideReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of arginine and lysine (cytosol to extracellular)
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by BTD, SLC3A2, SLC7A5, SLC7A6 and 3 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• CHEBI:16523Reach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glycine and lysine (cytosol to extracellular)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by BTD, SLC7A6, SLC3A2, SLC7A10mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of lysine and ornithine (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by BTD, SLC7A5, SLC7A6, ACY1mitochondrial matrix, extracellular space, cytosol

• 2-phenylacetamideReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of lysine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by BTD, SLC7A6, EPXmitochondrial matrix, extracellular space, cytosol

• CHEBI:16633Reach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of alanine and lysine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by BTD, SLC7A6, SCLYmitochondrial matrix, extracellular space, cytosol

• Met-tRNA(Met)Reach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of lysine and methionine (cytosol to extracellular)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by BTD, SLC7A6, MARS1mitochondrial matrix, extracellular space, cytosol

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of lysine and methionine (cytosol to extracellular)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by BTD, SLC7A6, AADATmitochondrial matrix, extracellular space, cytosol

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of lysine and phenylalanine (cytosol to extracellular)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by BTD, SLC7A6, CNDP2mitochondrial matrix, extracellular space, cytosol

• 2-oxobutanoateReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of lysine and threonine (cytosol to extracellular)
  3. L-threonine ammonia-lyase (2-oxobutanoate-forming)

  Catalysed by BTD, SLC7A6, SDS, SDSLmitochondrial matrix, extracellular space, cytosol

• tryptamineReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of lysine and tryptophan (cytosol to extracellular)
  3. L-tryptophan decarboxy-lyase

  Catalysed by BTD, SLC7A6, DDCmitochondrial matrix, extracellular space, cytosol

• 2-oxoglutaramateReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glutamine and lysine (cytosol to extracellular)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by BTD, SLC7A6, KYAT1mitochondrial matrix, extracellular space, cytosolOne of 3 routes