sulfite

Three steps

• guanidinoacetateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of Guanidinoacetic Acid

  Catalysed by SUOX, SLC26A6mitochondrial matrix, cytosol, extracellular space

• 3',5'-cyclic GMPReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3',5'-cyclic GMP(out) + a dicarboxylate(in) = 3',5'-cyclic GMP(in) + a dicarboxylate(out)

  Catalysed by SUOX, SLC25A35, SLC25A34, SLC22A6mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-threonineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)

  Catalysed by MPST, TST, AGXT2, SLC7A10cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• CMP-N-acetyl-beta-neuraminateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. CTP:N-acetylneuraminate cytidylyltransferase

  Catalysed by MPST, TST, NPL, CMAScytosol, nucleusOne of 2 routes

• adenosine 5'-phosphoramidateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. ATP:sulfate adenylyltransferase
  3. adenosine 5'-phosphosulfate + NH4(+) = adenosine 5'-phosphoramidate + sulfate + 2 H(+)

  Catalysed by SUOX, PAPSS1, PAPSS2, FHITmitochondrial matrix, cytosol

• L-tryptophanReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and tryptophan (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 12 routes

• L-threonineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)

  Catalysed by MPST, TST, AGXT2, SLC7A10cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 5 routes

• L-kynurenineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

  Catalysed by MPST, TST, AGXT2, KYNUcytosol, mitochondrial matrix

• beta-alanineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)

  Catalysed by MPST, TST, AGXT2, SLC7A10cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-hydroxy-3-oxopropanoateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. L-Serine:pyruvate aminotransferase
  3. hydroxypyruvate aldose-ketose-isomerase

  Catalysed by MPST, TST, AGXT, HYIcytosolOne of 2 routes

• L-asparagineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and asparagine (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 13 routes

• IMPReach from here →
  1. transport of fumarate and sulfite (cytosol to mitochondria)
  2. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  3. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)

  Catalysed by SLC25A10, ADSL, TNRC6B, ADSS2 and 1 moremitochondrial matrix, cytosol

• N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by SUOX, SLC25A14, SLC25A30, AGAmitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• L-phenylalanineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and phenylalanine (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 16 routes

• 3-hydroxy-L-kynurenineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

  Catalysed by MPST, TST, AGXT2, KYNUcytosol, mitochondrial matrix

• 3',5'-cyclic AMPReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3',5'-cyclic AMP(out) + a dicarboxylate(in) = 3',5'-cyclic AMP(in) + a dicarboxylate(out)

  Catalysed by SUOX, SLC25A35, SLC25A34, SLC22A6mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-homocysteineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by MPST, TST, TYW1B, TYW1 and 1 morecytosol

• S-methyl-L-methionineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by MPST, TST, TYW1B, TYW1 and 1 morecytosol

• N-acetylputrescineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N-acetylputrescine + H2O = putrescine + acetate

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• (2R)-2-phosphoglycerateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. pyruvate kinase (dTDP)
  3. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)

  Catalysed by MPST, TST, PKM, PKLR and 3 morecytosol

• taurolithocholate 3-sulfateReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. Persulfide dioxygenase
  3. transport of GSH and sulfotaurolithocholate (cytosol to extracellular)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• L-tyrosineReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)

  Catalysed by SUOX, SLC25A14, SLC25A30, SLC7A13mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by MPST, TST, AGXT2cytosol, mitochondrial matrixOne of 8 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by MPST, TST, AGXT2, SLC1A4cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 3 routes

• histamineReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. Persulfide dioxygenase
  3. transport of GSH and histamine (cytosol to extracellular)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• L-thyroxineReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. Persulfide dioxygenase
  3. transport of GSH and thyroxine (cytosol to extracellular)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• kynurenateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O

  Catalysed by MPST, TST, AADATcytosolOne of 5 routes

• 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideReach from here →
  1. transport of fumarate and sulfite (cytosol to mitochondria)
  2. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase
  3. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

  Catalysed by SLC25A10, ADSLmitochondrial matrix, cytosolOne of 2 routes

• N(8)-acetylspermidineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(8)-acetylspermidine + H2O = spermidine + acetate

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• (S)-3-amino-2-methylpropanoateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-3-amino-isobutanoate:2-oxoglutarate aminotransferase

  Catalysed by MPST, TST, AGXT2, ABATcytosol, mitochondrial matrix

• phosphoenolpyruvateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. Pyruvate:carbon-dioxide ligase (ADP-forming)
  3. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2

  Catalysed by MPST, TST, PC, PCK1 and 1 morecytosol, mitochondrial matrixOne of 3 routes

• an N-acetyl-L-cysteine-S-conjugateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. an N-acetyl-L-cysteine-S-conjugate + H2O = an S-substituted L-cysteine + acetate

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• D-glucosamineReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by SUOX, SGSHmitochondrial matrix, cytosol

• L-methionine (S)-S-oxideReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

  Catalysed by MPST, TST, TYW1B, TYW1 and 1 morecytosol

• L-methionine (R)-S-oxideReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

  Catalysed by MPST, TST, TYW1B, TYW1 and 3 morecytosol

• monodehydro-L-ascorbate radicalReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
  3. dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by TSTD1, CLIC1, GSTO1, GSTO2 and 1 moreOne of 11 routes

• (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by SUOX, SLC25A35, SLC25A34, SLC22A6 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 4-aminobutanoateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by SUOX, SLC26A6, SLC6A12mitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• dopamineReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. Persulfide dioxygenase
  3. transport of dopamine and GSH (cytosol to extracellular)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• (2S)-2-phospholactateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate

  Catalysed by MPST, TST, LDHA, LDHB and 4 morecytosolOne of 2 routes

• glycolithocholate 3-sulfateReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. Persulfide dioxygenase
  3. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• L-prolineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by MPST, TST, AGXT2, SLC1A4cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 3 routes

• prostaglandin E2Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. prostaglandin E2(out) + 2 (S)-lactate(in) = prostaglandin E2(in) + 2 (S)-lactate(out)

  Catalysed by MPST, TST, LDHA, LDHB and 4 morecytosol, inner side of the membrane, outer side of the membraneOne of 8 routes

• N-benzoylglycineReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)

  Catalysed by SUOX, SLC25A35, SLC25A34, SLC22A6 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-sulfino-L-alanineReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)

  Catalysed by SUOX, SLC25A14, SLC25A30, SLC25A12 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylateReach from here →
  1. transport of fumarate and sulfite (cytosol to mitochondria)
  2. a quinone + succinate = fumarate + a quinol
  3. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)

  Catalysed by SLC25A10, SDHB, PRODH2mitochondrial matrix, cytosol

• leukotriene D4Reach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. leukotriene C4 = leukotriene A4 + glutathione
  3. leukotriene C4 + H2O = leukotriene D4 + L-glutamate

  Catalysed by TSTD1, MGST3, GSTM4, LTC4S and 3 more

• dTMPReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. pyruvate kinase (dTDP)
  3. DTDP Diphosphohydrolase

  Catalysed by MPST, TST, PKM, PKLR and 3 morecytosol, extracellular spaceOne of 5 routes

• xanthurenateReach from here →
  1. transport of malate and sulfite (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O

  Catalysed by SLC25A10, CLYBL, KYAT3, AADATmitochondrial matrix, cytosol

• Mo-molybdopterinReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by MPST, TST, AGXT2, MOCOScytosol, mitochondrial matrix