L-methionine (S)-S-oxide

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

Catalysed by MSRA

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. N-acetylglutamate synthase (N-acetylmethionine)

Catalysed by MSRA, NAGSmitochondrial matrix

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. transport of leucine and methionine (cytosol to extracellular)

Catalysed by MSRA, SLC3A2, SLC7A5extracellular space, cytosolOne of 6 routes

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. transport of homoserine and methionine (cytosol to extracellular)

Catalysed by MSRA, SLC7A5extracellular space, cytosolOne of 3 routes

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. transport of histidine and methionine (cytosol to extracellular)

Catalysed by MSRA, SLC7A6extracellular space, cytosolOne of 2 routes

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. transport of citrulline and methionine (cytosol to extracellular)

Catalysed by MSRA, SLC7A6extracellular space, cytosolOne of 2 routes

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. transport of methionine and valine (cytosol to extracellular)

Catalysed by MSRA, SLC7A5extracellular space, cytosolOne of 3 routes

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. transport of arginine and methionine (cytosol to extracellular)

Catalysed by MSRA, SLC7A6extracellular space, cytosolOne of 5 routes

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. PROTEIN_BS

Catalysed by MSRAcytosol

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. L-Methionine:tRNAMet ligase (AMP-forming)

Catalysed by MSRA, MARS1cytosol

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

Catalysed by MSRA, AADAT

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. transport of methionine and threonine (cytosol to extracellular)

Catalysed by MSRA, SLC7A5extracellular space, cytosolOne of 3 routes

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. transport of isoleucine and methionine (cytosol to extracellular)

Catalysed by MSRA, SLC7A5extracellular space, cytosolOne of 3 routes

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. transport of methionine and proline (cytosol to extracellular)

Catalysed by MSRA, SLC7A5extracellular space, cytosolOne of 3 routes

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

Catalysed by MSRA, CDKAL1One of 3 routes

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. transport of cysteine and methionine (cytosol to extracellular)

Catalysed by MSRA, SLC7A5extracellular space, cytosolOne of 6 routes

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. transport of methionine and tyrosine (cytosol to extracellular)

Catalysed by MSRA, SLC7A5extracellular space, cytosolOne of 4 routes

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. transport of lysine and methionine (cytosol to extracellular)

Catalysed by MSRA, SLC7A6extracellular space, cytosolOne of 2 routes

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. transport of glutamine and methionine (cytosol to extracellular)

Catalysed by MSRA, SLC7A5extracellular space, cytosolOne of 6 routes

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

Catalysed by MSRA, SLC7A8inner side of the membrane, outer side of the membraneOne of 2 routes

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. transport of chloride and methionine (cytosol to extracellular)

Catalysed by MSRA, SLC6A14extracellular space, cytosolOne of 2 routes

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)

Catalysed by MSRA, SLC7A13inner side of the membrane, outer side of the membraneOne of 2 routes

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. L-Methionine:oxygen oxidoreductase (deaminating)

Catalysed by MSRA, IL4I1cytosol

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. transport of methionine and ornithine (cytosol to extracellular)

Catalysed by MSRA, SLC7A6extracellular space, cytosolOne of 2 routes

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. transport of glycine and methionine (cytosol to extracellular)

Catalysed by MSRA, SLC7A5extracellular space, cytosolOne of 5 routes

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. transport of methionine and tryptophan (cytosol to extracellular)

Catalysed by MSRA, SLC7A5extracellular space, cytosolOne of 4 routes

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. transport of alanine and methionine (cytosol to extracellular)

Catalysed by MSRA, SLC7A5extracellular space, cytosolOne of 7 routes

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. transport of asparagine and methionine (cytosol to extracellular)

Catalysed by MSRA, SLC7A5extracellular space, cytosolOne of 3 routes

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. transport of methionine and phenylalanine (cytosol to extracellular)

Catalysed by MSRA, SLC7A5extracellular space, cytosolOne of 6 routes

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

Catalysed by MSRA, BHMT2

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

Catalysed by MSRA, BHMT2

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

Catalysed by MSRA, MSRB3, MSRB1, MSRB2

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. transport of methionine and tryptophan (cytosol to extracellular)
3. beta-carboline hydrolysis

Catalysed by MSRA, SLC7A5extracellular space, cytosol

1. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol
2. N-acetylglutamate synthase (N-acetylmethionine)
3. Carnitine O-Palmitoyltransferase

Catalysed by MSRA, and 1 more