5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide

1. 2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)

Catalysed by SLC19A1inner side of the membrane, outer side of the membrane

1. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)

Catalysed by ATICcytosol

1. 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) + (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) + (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in)

Catalysed by SLC19A1inner side of the membrane, outer side of the membrane

1. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)

Catalysed by ATICcytosol

1. 10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate

Catalysed by ATIC

1. (6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate

Catalysed by ATIC

1. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

Catalysed by ADSLcytosolOne of 2 routes

1. (6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate

Catalysed by ATICOne of 2 routes

1. 3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)

Catalysed by SLC19A1inner side of the membrane, outer side of the membrane

1. (6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

Catalysed by ATIC, SHMT1, SHMT2One of 2 routes

1. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)

Catalysed by ATICcytosolOne of 4 routes

1. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
3. bile acid-CoA: amino acid N-acyltransferase

Catalysed by ATIC, SHMT1, BAATcytosol, peroxisomeOne of 29 routes

1. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
3. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine