L-thyroxine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

338 compounds within 3 steps: 7 in 1, 68 in 2, 263 in 3

One step

AReach from here →
1. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
Catalysed by DIO1, DIO3One of 2 routes
2,4-dinitrophenyl-S-glutathioneReach from here →
1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes
iodideReach from here →
1. 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)
Catalysed by DIO1, DIO2cytosolOne of 4 routes
CHEBI:16856Reach from here →
1. transport of GSH and thyroxine (cytosol to extracellular)
Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes
L-thyroxine sulfateReach from here →
1. L-thyroxine + 3'-phosphoadenylyl sulfate = L-thyroxine sulfate + adenosine 3',5'-bisphosphate + H(+)
Catalysed by SULT1A3, SULT1A4, SULT1A1
3,3',5-triiodo-L-thyronineReach from here →
1. 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)
Catalysed by DIO1, DIO2cytosolOne of 3 routes
3,3',5'-triiodo-L-thyronineReach from here →
1. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
Catalysed by DIO1, DIO3

Two steps

tauroursodeoxycholateReach from here →
1. transport of GSH and thyroxine (cytosol to extracellular)
2. transport of GSH and tauroursodeoxycholate (cytosol to extracellular)
Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes
glycoursodeoxycholateReach from here →
1. transport of GSH and thyroxine (cytosol to extracellular)
2. transport of glycoursodeoxycholate and GSH (cytosol to extracellular)
Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate

Reach from here →

Catalysed by SLCO1A2, SLCO1B3, PTGES, MGST3 and 19 moreextracellular space, cytosolOne of 4 routes

prostaglandin E3Reach from here →

Catalysed by SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

prostaglandin A2Reach from here →

Catalysed by SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

prostaglandin B1Reach from here →

Catalysed by SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

leukotriene F4Reach from here →

Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

acetylcholineReach from here →

Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

CHEBI:15650Reach from here →

Catalysed by SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

betaine aldehydeReach from here →

Catalysed by DIO1, DIO3, CHDH

bromideReach from here →

Catalysed by SLCO1A2, SLCO1B3, MGST3, GSTA4 and 15 moreextracellular space, cytosolOne of 2 routes

lithocholic acidReach from here →

Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

oxaloacetateReach from here →

Catalysed by DIO1, DIO3, D2HGDH

formaldehydeReach from here →

Catalysed by DIO1, DIO3, KDM1A, KDM1BOne of 3 routes

bilirubin IXalphaReach from here →

Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

taurolithocholateReach from here →

Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

CHEBI:17208Reach from here →

Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosol

homocysteineReach from here →

Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosol

all-trans-retinolReach from here →

Catalysed by DIO1, DIO3, RETSAT

AH2Reach from here →

Catalysed by DIO1, DIO3, AIFM1, PYROXD1One of 19 routes

L-cysteineReach from here →

Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

diiodineReach from here →

Catalysed by DIO1, DIO2, TPOcytosolOne of 2 routes

3,3',5-triiodo-L-thyronine sulfateReach from here →

Catalysed by DIO1, DIO2, SULT1A3, SULT1A4 and 2 morecytosolOne of 2 routes

3,3',5'-triiodo-L-thyronine sulfateReach from here →

Catalysed by DIO1, DIO3, SULT1B1, SULT1A3 and 2 moreOne of 2 routes

3,3'-diiodo-L-thyronineReach from here →

Catalysed by DIO1, DIO2, DIO3cytosolOne of 4 routes

3',5'-diiodo-L-thyronineReach from here →

Catalysed by DIO1, DIO3

5(S)-HETEReach from here →

Catalysed by SLCO1A2, SLCO1B3, GPX5, GPX1 and 7 moreextracellular space, cytosolOne of 2 routes

CHEBI:28666Reach from here →

Catalysed by SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

hypoioditeReach from here →

Catalysed by DIO1, DIO2, MPO, LPOcytosol

chlorine(.)Reach from here →

Catalysed by DIO1, DIO2, SLC26A4cytosol, extracellular space

glycocholateReach from here →

Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

cholateReach from here →

Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

serotoninReach from here →

Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

chenodeoxycholateReach from here →

Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

taurocholateReach from here →

Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

glycolithocholic acidReach from here →

Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

gamma-Glu-AlaReach from here →

Catalysed by SLCO1A2, SLCO1B3, GGT1, GGT5 and 4 moreextracellular space, cytosol

prostaglandin E1Reach from here →

Catalysed by SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

prostaglandin I2Reach from here →

Catalysed by SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

prostaglandin F2alphaReach from here →

Catalysed by SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

prostaglandin H2Reach from here →

Catalysed by SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

prostaglandin D2Reach from here →

Catalysed by SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes