dTMP

1. deoxythymidylate kinase (dADP)

Catalysed by DTYMKmitochondrial matrixOne of 2 routes

1. thymidylate 5'-phosphohydrolase

Catalysed by ACP3, NT5E, NT5C2, NT5C and 6 morecytosolOne of 4 routes

1. DTDP Diphosphohydrolase

Catalysed by ENTPD3, ENTPD1, ENTPD8extracellular spaceOne of 6 routes

1. dTTP + H2O = dTMP + diphosphate + H(+)

Catalysed by ASMTL

1. DTDP Diphosphohydrolase
2. pyruvate kinase (dTDP)

Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 1 moreextracellular space, cytosolOne of 2 routes

1. deoxythymidylate kinase (dADP)
2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase

Catalysed by DTYMK, TXN, RRM1, RRM2 and 2 moremitochondrial matrix

1. DTDP Diphosphohydrolase
2. pyruvate kinase (dTDP)
3. transport of 2-hydroxybutyrate and pyruvate (cytosol to extracellular)

Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 7 moreextracellular space, cytosolOne of 2 routes

1. DTDP Diphosphohydrolase
2. pyruvate kinase (dTDP)
3. transport of acetoacetate and pyruvate (cytosol to mitochondria)

Catalysed by and 1 more