iodide

Three steps

• trimethylenediamineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and lysine (cytosol to extracellular)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by SLC26A4, SLC6A14, DHPSextracellular space, cytosol

• CHEBI:15727Reach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and histidine (cytosol to extracellular)
  3. L-histidine:beta-alanine ligase (ADP-forming)

  Catalysed by SLC26A4, SLC6A14, CARNS1extracellular space, cytosolOne of 2 routes

• hexadecanoic acidReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC26A4, SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• CHEBI:15765Reach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Tyrosine by Atb0 Transporter
  3. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by SLC26A4, SLC6A14, THextracellular space, cytosolOne of 5 routes

• malonateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)

  Catalysed by SLC26A4, SLC26A6, SLC25A14, SLC25A30 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• bromideReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. 2-bromoacetaldehyde:glutathione S-(formylmethyl)transferase

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 18 morecytosol, extracellular spaceOne of 2 routes

• alpha-D-glucosamine 6-phosphateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by SLC26A4, SLC6A14, GFPT2, GFPT1extracellular space, cytosol

• ureaReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-Arginine amidinohydrolase

  Catalysed by SLC26A4, SLC6A14, ARG1extracellular space, cytosolOne of 3 routes

• succinic semialdehydeReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
  3. 4-aminobutanoate:2-oxoglutarate aminotransferase

  Catalysed by SLC26A4, SLC6A12, ABATextracellular space, cytosol, mitochondrial matrix

• L-cystineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by SLC26A4, SLC6A14, SLC7A9, SLC3A1extracellular space, cytosolOne of 7 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC26A4, SLC6A14, AGXT2extracellular space, cytosol, mitochondrial matrix

• lithocholic acidReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and lithocholate (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 4 routes

• (R)-carnitineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of betaine and chloride (cytosol to extracellular)
  3. glycine betaine(out) + (R)-carnitine(in) = glycine betaine(in) + (R)-carnitine(out)

  Catalysed by SLC26A4, SLC6A12, SLC22A5extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-citrullineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of citrulline and glycine (cytosol to extracellular)

  Catalysed by SLC26A4, SLC6A9, SLC6A14, SLC7A9 and 2 moreextracellular space, cytosolOne of 39 routes

• oxaloacetateReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  3. (R)-malate + A = oxaloacetate + AH2

  Catalysed by DIO1, DIO3, DIO2, D2HGDHcytosol

• nitric oxideReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by SLC26A4, SLC6A14, NOS3, NOS1 and 1 moreextracellular space, cytosolOne of 2 routes

• CHEBI:16523Reach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by SLC26A4, SLC6A9, SLC6A14, SLC3A2 and 1 moreextracellular space, cytosolOne of 4 routes

• protein polypeptide chainReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. PROTEIN_BS

  Catalysed by SLC26A4, SLC6A9, SLC6A14extracellular space, cytosolOne of 17 routes

• 2-phenylacetamideReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by SLC26A4, SLC6A14, EPXextracellular space, cytosol

• CHEBI:16633Reach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC26A4, SLC6A14, SCLYextracellular space, cytosol

• Met-tRNA(Met)Reach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by SLC26A4, SLC6A14, MARS1extracellular space, cytosol

• quinolinic acidReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of Quinolinic Acid

  Catalysed by SLC26A4, SLC26A6, SLC22A6extracellular space, cytosolOne of 2 routes

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by SLC26A4, SLC6A14, AADATextracellular space, cytosol

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by SLC26A4, SLC6A14, CNDP2extracellular space, cytosol

• 2-oxobutanoateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Threonine by Atb0 Transporter
  3. L-threonine ammonia-lyase (2-oxobutanoate-forming)

  Catalysed by SLC26A4, SLC6A14, SDS, SDSLextracellular space, cytosol

• tryptamineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-tryptophan decarboxy-lyase

  Catalysed by SLC26A4, SLC6A14, DDCextracellular space, cytosol

• 2-oxoglutaramateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by SLC26A4, SLC6A14, KYAT1extracellular space, cytosolOne of 3 routes

• formaldehydeReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  3. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2

  Catalysed by DIO1, DIO3, DIO2, KDM1A and 1 morecytosolOne of 3 routes

• glyoxylic acidReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC26A4, SLC6A9, SLC6A14, DAOextracellular space, cytosol, peroxisome

• creatineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of Guanidinoacetic Acid
  3. S-Adenosyl-L-methionine:guanidinoacetate N-methyltransferase

  Catalysed by SLC26A4, GAMTextracellular space, cytosolOne of 2 routes

• bilirubin IXalphaReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of bilirubin and GSH (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 4 routes

• (R)-3-hydroxybutyric acidReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of (R)-3-hydroxybutanoate and formate (cytosol to extracellular)

  Catalysed by SLC26A4, SLC16A4, SLC16A5, SLC16A7 and 1 moreextracellular space, cytosolOne of 2 routes

• 2-aminoacrylic acidReach from here →
  1. iodide:hydrogen-peroxide oxidoreductase
  2. thyroid peroxidase (iodine)
  3. thyroid peroxidase (3,5-diiodo-L-tyrosine)

  Catalysed by TPOcytosolOne of 3 routes

• taurolithocholateReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and taurolithocholate (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 6 routes

• CHEBI:17208Reach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. glutathione:dehydroascorbate oxidoreductase

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular space

• homocysteineReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. Formation of Homocystine

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular space

• all-trans-retinolReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

  Catalysed by DIO1, DIO3, DIO2, RETSATcytosol

• linoleic acidReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC26A4, SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• sulfiteReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)

  Catalysed by SLC26A4, SLC26A6, SLC25A14, SLC25A30extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• D-aspartic acidReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. transport of D-aspartate (cytosol to extracellular)

  Catalysed by SLC26A4, SLC12A2, SLC12A1, SLC1A7 and 4 moreextracellular space, cytosol

• CHEBI:17380Reach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by SLC26A4, SLC6A14, SLC7A5extracellular space, cytosolOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Proline by the Apical Imino Amino Acid Transporters
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by SLC26A4, CLTRN, SLC6A20, PRODH2extracellular space, cytosolOne of 2 routes

• agmatineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by SLC26A4, SLC6A14extracellular space, cytosol, mitochondrial matrix

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. palmitoyl-CoA:L-carnitine O-palmitoyltransferase

  Catalysed by SLC26A4, SLC6A14, CPT2, CPT1Aextracellular space, cytosol, peroxisomeOne of 10 routes

• AH2Reach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  3. A + NADH + H(+) = AH2 + NAD(+)

  Catalysed by DIO1, DIO3, DIO2, AIFM1 and 1 morecytosolOne of 25 routes

• 5-aminolevulinic acidReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by SLC26A4, SLC6A9, SLC6A14, ALAS1 and 2 moreextracellular space, cytosol, mitochondrial matrix

• indole-3-pyruvateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by SLC26A4, SLC6A14, IL4I1extracellular space, cytosolOne of 2 routes

• 3,3',5'-triiodo-L-thyronine sulfateReach from here →
  1. 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)
  2. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
  3. 3,3',5'-triiodo-L-thyronine + 3'-phosphoadenylyl sulfate = 3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by DIO1, DIO2, DIO3, SULT1B1 and 3 morecytosolOne of 2 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  3. Steryl-Sulfatase

  Catalysed by DIO1, DIO3, DIO2, STScytosol, Golgi apparatusOne of 7 routes

• CHEBI:17724Reach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of betaine and chloride (cytosol to extracellular)
  3. Trimethylaminoacetate:L-homosysteine S-methyltransferase

  Catalysed by SLC26A4, SLC6A12, BHMT, BHMT2extracellular space, cytosol