Compound
formaldehyde
A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)
Structure
Loading the model…
- Class
- Organic compound
- Formula
- CH2O
- Mass
- 30.026 g/mol
- Charge
- 0
- InChIKey
- WSFSSNUMVMOOMR-UHFFFAOYSA-N
- SMILES
- [H]C([H])=O
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
27 entities
27 entities reached.
0 reported hops27 assembled from the scaffold
- KDM6AProteinUNIPROT:O15550substrate ofInferred only39 paths28 endpoints
- KDM4AProteinUNIPROT:O75164substrate ofInferred only34 paths16 endpoints
- JMJD6ProteinUNIPROT:Q6NYC1substrate ofInferred only21 paths7 endpoints
- ADH1AProteinUNIPROT:P07327metabolized byInferred only17 paths17 endpoints
- ADH5ProteinUNIPROT:P11766metabolized byInferred only16 paths16 endpoints
- FTOProteinUNIPROT:Q9C0B1substrate ofInferred only15 paths5 endpoints
- KDM5AProteinUNIPROT:P29375substrate ofInferred only15 paths13 endpoints
- KDM5BProteinUNIPROT:Q9UGL1substrate ofInferred only14 paths14 endpoints
- KDM6BProteinUNIPROT:O15054substrate ofInferred only13 paths13 endpoints
- KDM4CProteinUNIPROT:Q9H3R0substrate ofInferred only12 paths10 endpoints
- KDM4BProteinUNIPROT:O94953substrate ofInferred only12 paths12 endpoints
- ADH7ProteinUNIPROT:P40394metabolized byInferred only12 paths12 endpoints
Show the remaining 15
- ADH1CProteinUNIPROT:P00326metabolized byInferred only11 paths11 endpoints
- SELENBP1ProteinUNIPROT:Q13228substrate ofInferred only10 paths10 endpoints
- ALDH9A1ProteinUNIPROT:P49189metabolized byInferred only7 paths7 endpoints
- ALKBH3ProteinUNIPROT:Q96Q83substrate ofInferred only6 paths6 endpoints
- PIPOXProteinUNIPROT:Q9P0Z9substrate ofInferred only6 paths6 endpoints
- ADH6ProteinUNIPROT:P28332metabolized byInferred only5 paths5 endpoints
- ADHFE1ProteinUNIPROT:Q8IWW8substrate ofInferred only5 paths5 endpoints
- PDPRProteinUNIPROT:Q8NCN5substrate ofInferred only5 paths5 endpoints
- KDM5DProteinUNIPROT:Q9BY66substrate ofInferred only5 paths5 endpoints
- KDM4DProteinUNIPROT:Q6B0I6substrate ofInferred only4 paths4 endpoints
- DMGDHProteinUNIPROT:Q9UI17substrate ofInferred only4 paths4 endpoints
- KDM5CProteinUNIPROT:P41229substrate ofInferred only4 paths4 endpoints
- KDM4EProteinUNIPROT:B2RXH2substrate ofInferred only3 paths3 endpoints
- UTYProteinUNIPROT:O14607substrate ofInferred only3 paths3 endpoints
- ALKBH1ProteinUNIPROT:Q13686substrate ofInferred only1 path1 endpoint
What the reference databases state
Statements
46 statements
46 statements · 2 reference databases · Subject: formaldehyde · Sources: Human-GEM, Rhea
- formaldehyde is converted to formateCompoundRhea RHEA:16425Inferred only
- formate is converted to formaldehydeCompoundRhea RHEA:16425Inferred only
- formaldehyde is converted to methanolCompoundRhea RHEA:30691Inferred only
- methanol is converted to formaldehydeCompoundRhea RHEA:19401Inferred only
- methanol is converted to formaldehydeCompoundHuman-GEM MAR04202Inferred only
- methanol is converted to formaldehydeCompoundHuman-GEM MAR08752Inferred only
- methanol is converted to formaldehydeCompoundHuman-GEM MAR04201Inferred only
- methanol is converted to formaldehydeCompoundRhea RHEA:30691Inferred only
- formaldehyde is converted to methanolCompoundRhea RHEA:19401Inferred only
- methylamine is converted to formaldehydeCompoundRhea RHEA:76823Inferred only
- formaldehyde is converted to methylamineCompoundRhea RHEA:76823Inferred only
- methylamine is converted to formaldehydeCompoundHuman-GEM MAR08529Inferred only
Show the remaining 34
- methylamine is converted to formaldehydeCompoundRhea RHEA:59420Inferred only
- formaldehyde is metabolised by ADH1AProteinHuman-GEM MAR08530Inferred only
- formaldehyde is metabolised by ADH1CProteinHuman-GEM MAR08530Inferred only
- formaldehyde is metabolised by ADH5ProteinHuman-GEM MAR08530Inferred only
- formaldehyde is metabolised by ADH6ProteinHuman-GEM MAR08530Inferred only
- formaldehyde is metabolised by ADH7ProteinHuman-GEM MAR08530Inferred only
- formaldehyde is metabolised by ALDH9A1ProteinRhea RHEA:16425Inferred only
- formaldehyde is a substrate of ADHFE1ProteinHuman-GEM MAR08530Inferred only
- formaldehyde is a substrate of ALKBH1ProteinRhea RHEA:79019Inferred only
- formaldehyde is a substrate of ALKBH3ProteinRhea RHEA:49516Inferred only
- formaldehyde is a substrate of DMGDHProteinHuman-GEM MAR04700Inferred only
- formaldehyde is a substrate of FTOProteinRhea RHEA:57904Inferred only
- formaldehyde is a substrate of FTOProteinRhea RHEA:57900Inferred only
- formaldehyde is a substrate of FTOProteinRhea RHEA:57896Inferred only
- formaldehyde is a substrate of JMJD6ProteinRhea RHEA:58348Inferred only
- formaldehyde is a substrate of JMJD6ProteinRhea RHEA:58784Inferred only
- formaldehyde is a substrate of JMJD6ProteinRhea RHEA:58472Inferred only
- formaldehyde is a substrate of KDM4AProteinRhea RHEA:60200Inferred only
- formaldehyde is a substrate of KDM4AProteinRhea RHEA:60236Inferred only
- formaldehyde is a substrate of KDM4BProteinRhea RHEA:60200Inferred only
- formaldehyde is a substrate of KDM4CProteinRhea RHEA:60200Inferred only
- formaldehyde is a substrate of KDM4DProteinRhea RHEA:60200Inferred only
- formaldehyde is a substrate of KDM4EProteinRhea RHEA:60200Inferred only
- formaldehyde is a substrate of KDM4FProteinRhea RHEA:60200Inferred only
- formaldehyde is a substrate of KDM5AProteinRhea RHEA:60208Inferred only
- formaldehyde is a substrate of KDM5BProteinRhea RHEA:60208Inferred only
- formaldehyde is a substrate of KDM5CProteinRhea RHEA:60208Inferred only
- formaldehyde is a substrate of KDM5DProteinRhea RHEA:60208Inferred only
- formaldehyde is a substrate of KDM6AProteinRhea RHEA:60224Inferred only
- formaldehyde is a substrate of KDM6BProteinRhea RHEA:60224Inferred only
- formaldehyde is a substrate of PDPRProteinHuman-GEM MAR04700Inferred only
- formaldehyde is a substrate of PIPOXProteinRhea RHEA:13313Inferred only
- formaldehyde is a substrate of SELENBP1ProteinRhea RHEA:11812Inferred only
- formaldehyde is a substrate of UTYProteinRhea RHEA:60224Inferred only
Reactions
174 reactions
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR01946CC BY 4.0Reference data
Reaction pageReversibleBalancedEC 4.2.1.1extracellular space, cytosol
Human-GEM MAR02346CC BY 4.0Reference data
proton+NADPH(4-)+dioxygen+MAM03323cformaldehyde+water+NADP(3-)+MAM03324c
Reaction pageLeft to rightBalancedEC 1.14.14.55cytosol
Human-GEM MAR03133CC BY 4.0Reference data
proton+NADPH(4-)+dioxygen+MAM03323rformaldehyde+water+NADP(3-)+MAM03324r
Catalysed by CYP3A4
Reaction pageLeft to rightBalancedEC 1.14.14.55endoplasmic reticulum
Human-GEM MAR03134CC BY 4.0Reference data
FAD+water+CHEBI:15611FADH2+formaldehyde+glycine
Reaction pageLeft to rightBalancedEC 1.5.3.1, 1.5.8.3peroxisome
Human-GEM MAR03849CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, peroxisome
Human-GEM MAR03867CC BY 4.0Reference data
formaldehyde+CHEBI:16856MAM02152c
Reaction pageReversibleBalancedEC 4.4.1.22cytosol
Human-GEM MAR03935CC BY 4.0Reference data
formaldehyde+5,6,7,8-tetrahydrofolic acid(6R)-5,10-methylenetetrahydrofolic acid+water
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR03972CC BY 4.0Reference data
hydrogen peroxide+methanolformaldehyde+2water
Catalysed by PRDX6 or EPX or CAT or PXDN or LPO
Reaction pageLeft to rightBalancedEC 1.11.1.6, 1.11.1.7cytosol
Human-GEM MAR04201CC BY 4.0Reference data
methanol+NAD(+)formaldehyde+proton+NADH(2-)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedEC 1.1.1.244cytosol
Human-GEM MAR04202CC BY 4.0Reference data
MAM01160c+waterformaldehyde+serotonin
Reaction pageReversibleBalancedcytosol
Human-GEM MAR04554CC BY 4.0Reference data
formaldehyde+proton+NADPH(4-)+CHEBI:15611CHEBI:17724+water+NADP(3-)
Reaction pageReversibleBalancedEC 1.5.8.4cytosol
Human-GEM MAR04700CC BY 4.0Reference data
Other names
5 names
Resolves to: formaldehyde
- Also called
- FORMALINMethanalMethylene oxideOxomethaneOxomethylene