Compound
homocysteine
A thiol-containing amino acid formed by a demethylation of methionine.
What it touches on the way
Mechanistic reach
7 entities
7 entities reached.
0 reported hops7 assembled from the scaffold
- MTRProteinUNIPROT:Q99707substrate ofInferred only40 paths40 endpoints
- CBSProteinUNIPROT:P35520substrate ofInferred only32 paths32 endpoints
- BHMTProteinUNIPROT:Q93088substrate ofInferred only14 paths14 endpoints
- PON2ProteinUNIPROT:Q15165substrate ofInferred only11 paths11 endpoints
- PON3ProteinUNIPROT:Q15166substrate ofInferred only9 paths9 endpoints
- PON1ProteinUNIPROT:P27169substrate ofInferred only9 paths9 endpoints
- BHMT2ProteinUNIPROT:Q9H2M3substrate ofInferred only5 paths5 endpoints
What the reference databases state
Statements
10 statements
10 statements · 1 reference database · Subject: homocysteine · Sources: Human-GEM
- homocysteine is converted to L-homocysteine thiolactoneCompoundHuman-GEM MAR03920Inferred only
- L-homocysteine thiolactone is converted to homocysteineCompoundHuman-GEM MAR03920Inferred only
- homocysteine is converted to L,L-cystathionineCompoundHuman-GEM MAR03879Inferred only
- homocysteine is a substrate of BHMTProteinHuman-GEM MAR04699Inferred only
- homocysteine is a substrate of BHMT2ProteinHuman-GEM MAR04699Inferred only
- homocysteine is a substrate of CBSProteinHuman-GEM MAR03879Inferred only
- homocysteine is a substrate of MTRProteinHuman-GEM MAR03917Inferred only
- homocysteine is a substrate of PON1ProteinHuman-GEM MAR03920Inferred only
- homocysteine is a substrate of PON2ProteinHuman-GEM MAR03920Inferred only
- homocysteine is a substrate of PON3ProteinHuman-GEM MAR03920Inferred only
Reactions
8 reactions
water+CHEBI:16680adenosine+homocysteine
Reaction pageLeft to rightBalancedEC 3.13.2.1cytosol
Human-GEM MAR03877CC BY 4.0Reference data
homocysteine+L-seryl residuewater+L,L-cystathionine
Catalysed by CBS
Reaction pageLeft to rightBalancedEC 4.2.1.22cytosol
Human-GEM MAR03879CC BY 4.0Reference data
5-methyltetrahydrofolic acid+homocysteineproton+L-methionine+5,6,7,8-tetrahydrofolic acid
Catalysed by MTR
Reaction pageLeft to rightBalancedEC 2.1.1.13cytosol
Human-GEM MAR03917CC BY 4.0Reference data
water+L-homocysteine thiolactoneproton+homocysteine
Catalysed by PON1 or PON3 or PON2
Reaction pageReversibleBalancedEC 3.1.1.2cytosol
Human-GEM MAR03920CC BY 4.0Reference data
glycine betaine+homocysteineCHEBI:17724+L-methionine
Reaction pageLeft to rightBalancedEC 2.1.1.5cytosol
Human-GEM MAR04699CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR09853CC BY 4.0Reference data
2CHEBI:16856+MAM03394cglutathione disulfide+2homocysteine
Reaction pageReversibleBalancedcytosol
Human-GEM MAR11299CC BY 4.0Reference data
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR11313CC BY 4.0Reference data
Other names
3 names
Resolves to: homocysteine
- Also called
- 2-Amino-4-mercaptobutyric acidHcy
- Systematic name
- 2-amino-4-sulfanylbutanoic acid