homocysteine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

546 compounds within 3 steps: 6 in 1, 90 in 2, 450 in 3

One step

CHEBI:16856Reach from here →
1. Formation of Homocystine
No catalyst recordedcytosol
CHEBI:17724Reach from here →
1. Trimethylaminoacetate:L-homosysteine S-methyltransferase
Catalysed by BHMT, BHMT2cytosol
5,6,7,8-tetrahydrofolic acidReach from here →
1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
Catalysed by MTRcytosol
L-homocysteine thiolactoneReach from here →
1. arylesterase (homocysteine-thiolactone)
Catalysed by PON1, PON2, PON3cytosol
L-methionineReach from here →
1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
Catalysed by MTRcytosolOne of 2 routes
L,L-cystathionineReach from here →
1. L-serine hydro-lyase (adding homocysteine
Catalysed by CBScytosol

Two steps

CHEBI:1146900Reach from here →
1. L-serine hydro-lyase (adding homocysteine
2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)
Catalysed by CBS, NAGScytosol, mitochondrial matrixOne of 2 routes
tauroursodeoxycholateReach from here →
1. Formation of Homocystine
2. transport of GSH and tauroursodeoxycholate (cytosol to extracellular)
Catalysed by SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes
glycoursodeoxycholateReach from here →

Catalysed by SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoateReach from here →

Catalysed by PTGES, MGST3, GSTA4, GSTZ1 and 17 morecytosolOne of 4 routes

prostaglandin E3Reach from here →

Catalysed by SLCO2A1cytosol, extracellular spaceOne of 2 routes

prostaglandin A2Reach from here →

Catalysed by SLCO2A1cytosol, extracellular spaceOne of 2 routes

prostaglandin B1Reach from here →

Catalysed by SLCO2A1cytosol, extracellular spaceOne of 2 routes

leukotriene F4Reach from here →

No catalyst recordedcytosol, extracellular spaceOne of 2 routes

acetylcholineReach from here →

Catalysed by SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

L-leucineReach from here →

Catalysed by MTR, SLC3A2, SLC7A5cytosol, extracellular spaceOne of 6 routes

CHEBI:15611Reach from here →

Catalysed by BHMT, BHMT2, PDPR, DMGDHcytosolOne of 3 routes

10-formyltetrahydrofolic acidReach from here →

Catalysed by MTR, MTHFD1cytosolOne of 3 routes

5-methyltetrahydrofolic acidReach from here →

Catalysed by MTR, HNMTcytosol

CHEBI:15650Reach from here →

Catalysed by SLCO1B1cytosol, extracellular spaceOne of 2 routes

CHEBI:15699Reach from here →

Catalysed by MTR, SLC7A5cytosol, extracellular spaceOne of 3 routes

bromideReach from here →

Catalysed by MGST3, GSTA4, GSTA1, GSTA2 and 13 morecytosolOne of 2 routes

CHEBI:15971Reach from here →

Catalysed by MTR, SLC7A6cytosol, extracellular spaceOne of 2 routes

lithocholic acidReach from here →

Catalysed by SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

L-citrullineReach from here →

Catalysed by MTR, SLC7A6cytosol, extracellular spaceOne of 2 routes

L-valineReach from here →

Catalysed by MTR, SLC7A5cytosol, extracellular spaceOne of 3 routes

L-arginineReach from here →

Catalysed by MTR, SLC7A6cytosol, extracellular spaceOne of 5 routes

protein polypeptide chainReach from here →

Catalysed by MTRcytosol

Met-tRNA(Met)Reach from here →

Catalysed by MTR, MARS1cytosol

4-methylsulfanyl-2-oxobutanoateReach from here →

Catalysed by MTR, AADATcytosol

2-oxobutanoateReach from here →

Catalysed by CBS, CTHcytosolOne of 2 routes

formaldehydeReach from here →

Catalysed by BHMT, BHMT2, PDPR, DMGDHcytosolOne of 2 routes

CHEBI:16857Reach from here →

Catalysed by MTR, SLC7A5cytosol, extracellular spaceOne of 3 routes

bilirubin IXalphaReach from here →

Catalysed by SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

taurolithocholateReach from here →

Catalysed by SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

L-isoleucineReach from here →

Catalysed by MTR, SLC7A5cytosol, extracellular spaceOne of 3 routes

CHEBI:17203Reach from here →

Catalysed by MTR, SLC7A5cytosol, extracellular spaceOne of 3 routes

CHEBI:17208Reach from here →

No catalyst recordedcytosol

AH2Reach from here →

Catalysed by MTR, CDKAL1cytosolOne of 3 routes

L-cysteineReach from here →

Catalysed by CBS, CTHcytosolOne of 9 routes

CHEBI:17895Reach from here →

Catalysed by MTR, SLC7A5cytosol, extracellular spaceOne of 4 routes

CHEBI:18019Reach from here →

Catalysed by MTR, SLC7A6cytosol, extracellular spaceOne of 2 routes

L-glutamineReach from here →

Catalysed by MTR, SLC7A5cytosol, extracellular spaceOne of 6 routes

S-methylmercury-L-cysteineReach from here →

Catalysed by MTR, SLC7A8cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

(6R)-5,10-methylenetetrahydrofolic acidReach from here →

Catalysed by MTR, SHMT1cytosolOne of 5 routes

5(S)-HETEReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosolOne of 2 routes

CHEBI:28666Reach from here →

Catalysed by SLCO2A1cytosol, extracellular spaceOne of 2 routes

chlorine(.)Reach from here →

Catalysed by MTR, SLC6A14cytosol, extracellular spaceOne of 2 routes

glycocholateReach from here →

Catalysed by SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

cholateReach from here →

Catalysed by SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes