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Proteins/UNIPROT:Q8N465
Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC..
Function from UniProtKB (Q8N465), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
19 statements
19 statements · 6 reference databases · Subject: D2HGDH · Sources: Bgee, Hetionet, Reactome, Rhea, UniProt, WikiPathways
2 reactions
(R)-2-hydroxyglutarate+A2-oxoglutarate(2-)+AH2
Catalysed by D2HGDH
Reaction pageLeft to rightBalanced
Rhea RHEA:38295CC BY 4.0Reference data
Catalysed by D2HGDH
Reaction pageLeft to rightBalanced
Rhea RHEA:67460CC BY 4.0Reference data
2 names
Resolves to: D2HGDH