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Proteins/UNIPROT:O43704
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system..
Function from UniProtKB (O43704), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
28 statements
28 statements · 7 reference databases · Subject: SULT1B1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
12 reactions
6 names
Resolves to: SULT1B1
3,3'-diiodo-L-thyronine+3'-phospho-5'-adenylyl sulfate3,3'-diiodo-L-thyronine sulfate+proton+adenosine 3',5'-bismonophosphate
Catalysed by NDST1 or UST or CHST10 or SULT4A1 or CHST7 or HS2ST1 or CHST9 or GAL3ST2 or NDST3 or SULT1B1 or HS6ST3 or GAL3ST4 and 2 more alternatives
Reaction pageLeft to rightBalancedEC 2.8.2.-cytosol
Human-GEM MAR06829CC BY 4.0Reference data
3'-phospho-5'-adenylyl sulfate+MAM02839c3,3',5-triiodo-L-thyronine sulfate+proton+adenosine 3',5'-bismonophosphate
Catalysed by SULT1B1 or SULT1C2
Reaction pageLeft to rightBalancedEC 2.8.2.-cytosol
Human-GEM MAR06838CC BY 4.0Reference data
MAM00736c+3'-phospho-5'-adenylyl sulfateMAM00737c+proton+adenosine 3',5'-bismonophosphate
Catalysed by SULT1B1 or SULT1C2
Reaction pageLeft to rightBalancedEC 2.8.2.-cytosol
Human-GEM MAR06844CC BY 4.0Reference data
MAM00828c+3'-phospho-5'-adenylyl sulfateMAM00829c+proton+adenosine 3',5'-bismonophosphate
Catalysed by SULT1B1 or SULT1C2
Reaction pageLeft to rightBalancedEC 2.8.2.-cytosol
Human-GEM MAR06850CC BY 4.0Reference data
a phenol+3'-phosphoadenylyl sulfatean aryl sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT1C2 or SULT1B1 or SULT1C4 or SULT1A3 or SULT1A4 or SULT1A1 or SULT1A2 or SULT1C3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:12164CC BY 4.0Reference data
3,3',5-triiodo-L-thyronine+3'-phosphoadenylyl sulfate3,3',5-triiodo-L-thyronine sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT1B1 or SULT1A3 or SULT1A4 or SULT1A1
Reaction pageLeft to rightBalanced
Rhea RHEA:67876CC BY 4.0Reference data
dopamine+3'-phosphoadenylyl sulfatedopamine 3-O-sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT1B1 or SULT1A3 or SULT1A4 or SULT1A1
Reaction pageLeft to rightBalanced
Rhea RHEA:67880CC BY 4.0Reference data
dopamine+3'-phosphoadenylyl sulfatedopamine 4-O-sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT1B1 or SULT1A3 or SULT1A4 or SULT1A1
Reaction pageLeft to rightBalanced
Rhea RHEA:67884CC BY 4.0Reference data
3,3',5'-triiodo-L-thyronine+3'-phosphoadenylyl sulfate3,3',5'-triiodo-L-thyronine sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT1B1 or SULT1A3 or SULT1A4 or SULT1A1
Reaction pageLeft to rightBalanced
Rhea RHEA:67888CC BY 4.0Reference data
3,3'-diiodo-L-thyronine+3'-phosphoadenylyl sulfate3,3'-diiodo-L-thyronine sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT1B1 or SULT1A3 or SULT1A4 or SULT1A1
Reaction pageLeft to rightBalanced
Rhea RHEA:67892CC BY 4.0Reference data
4-ethylphenol+3'-phosphoadenylyl sulfate4-ethylphenyl sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT1B1 or SULT1E1 or SULT1A1
Reaction pageLeft to rightBalanced
Rhea RHEA:70607CC BY 4.0Reference data