5-methyltetrahydrofolic acid

Three steps

• palmitoyl-CoAReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by MTR, NAGS, SLC27A2, ACSL4 and 6 morecytosol, mitochondrial matrixOne of 11 routes

• oleoyl-CoAReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by MTR, NAGS, CPT1A, CPT1C and 1 morecytosol, mitochondrial matrixOne of 11 routes

• phenylacetyl-CoAReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Phenylacetate:CoA ligase

  Catalysed by MTR, NAGScytosol, mitochondrial matrixOne of 3 routes

• propionyl-CoAReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by MTR, NAGS, ACSS3, ACSS2 and 1 morecytosol, mitochondrial matrixOne of 44 routes

• CHEBI:15570Reach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by MTR, SLC7A5, SLC3A2, SLC7A10cytosol, extracellular spaceOne of 5 routes

• CHEBI:15611Reach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by MTR, SLC7A5, GNMTcytosol, extracellular space

• (6R)-5,10-methylene-5,6,7,8-tetrahydrofolateReach from here →
  1. 5-methyl-THF to 5,10-methylene-THF conversion
  2. 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methenyltetrahydrofolate + NADH

  Catalysed by MTHFD2, MTHFD2Lcytosol, mitochondrial matrix

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by MTR, SLC7A5, TPH1, TPH2cytosol, extracellular spaceOne of 2 routes

• CHEBI:15650Reach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by MTR, NAGS, ZDHHC11B, NAA10 and 30 morecytosol, mitochondrial matrixOne of 2 routes

• trimethylenediamineReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of lysine and methionine (cytosol to extracellular)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by MTR, SLC7A6, DHPScytosol, extracellular space

• CHEBI:15727Reach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by MTR, NAGS, NAA10cytosol, mitochondrial matrixOne of 2 routes

• CHEBI:15746Reach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by MTR, NAGS, SAT1, SAT2cytosol, mitochondrial matrixOne of 2 routes

• N-carbamoyl-L-aspartic acidReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by MTR, SLC7A13, CADcytosol, inner side of the membrane, outer side of the membrane

• alpha-D-glucosamine 6-phosphateReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by MTR, SLC7A5, GFPT2, GFPT1cytosol, extracellular space

• thioredoxin dithiolReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. L-Methionine:tRNAMet ligase (AMP-forming)
  3. glycyl-tRNA(gly) phosphorylation

  Catalysed by MTR, MARS1cytosolOne of 2 routes

• CHEBI:16174Reach from here →
  1. 5-methyl-THF to 5,10-methylene-THF conversion
  2. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
  3. deoxythymidylate kinase (dADP)

  Catalysed by TYMS, DTYMKcytosol, mitochondrial matrixOne of 2 routes

• sulfateReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of chloride and methionine (cytosol to extracellular)
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by MTR, SLC6A14, SLC26A6cytosol, extracellular spaceOne of 3 routes

• ureaReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of arginine and methionine (cytosol to extracellular)
  3. L-Arginine amidinohydrolase

  Catalysed by MTR, SLC7A6, ARG1cytosol, extracellular spaceOne of 3 routes

• L-cystineReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of alanine and methionine (cytosol to extracellular)
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by MTR, SLC7A5, SLC7A9, SLC3A1cytosol, extracellular spaceOne of 9 routes

• 11-cis-retinolReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by MTR, NAGS, DGAT1, LRAT and 3 morecytosol, mitochondrial matrix

• cob(II)alaminReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 2 cob(II)alamin + A + 2 H2O + 2 H(+) = 2 aquacob(III)alamin + AH2

  Catalysed by MTR, CDKAL1, MTRRcytosol

• (R)-3-aminoisobutyric acidReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of alanine and methionine (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by MTR, SLC7A5, AGXT2cytosol, extracellular space, mitochondrial matrix

• iodideReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of methionine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by MTR, SLC7A5, TPOcytosol, extracellular spaceOne of 25 routes

• oxaloacetateReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. ATP citrate lyase (citrate)

  Catalysed by MTR, NAGS, ACLYcytosol, mitochondrial matrixOne of 6 routes

• nitric oxideReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of arginine and methionine (cytosol to extracellular)
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by MTR, SLC7A6, NOS3, NOS1 and 1 morecytosol, extracellular spaceOne of 3 routes

• CHEBI:16523Reach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by MTR, SLC7A5, SLC3A2, SLC7A10cytosol, extracellular spaceOne of 4 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by MTR, SLC7A6, ACY1cytosol, extracellular space

• 2-phenylacetamideReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of methionine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by MTR, SLC7A5, EPXcytosol, extracellular space

• CHEBI:16633Reach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of alanine and methionine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by MTR, SLC7A5, SCLYcytosol, extracellular space

• 3'-deoxy-3',4'-didehydro-CTPReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. CTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)

  Catalysed by MTR, CDKAL1, RSAD2cytosol

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of methionine and phenylalanine (cytosol to extracellular)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by MTR, SLC7A5, CNDP2cytosol, extracellular space

• tryptamineReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. L-tryptophan decarboxy-lyase

  Catalysed by MTR, SLC7A5, DDCcytosol, extracellular space

• 2-oxoglutaramateReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by MTR, SLC7A5, KYAT1cytosol, extracellular spaceOne of 3 routes

• (S)-2-hydroxyglutarateReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2

  Catalysed by MTR, CDKAL1, L2HGDHcytosol

• CHEBI:16856Reach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by MTR, SLC7A5, GSScytosol, extracellular spaceOne of 2 routes

• glyoxylic acidReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by MTR, SLC7A5, DAOcytosol, extracellular space, peroxisome

• N-acetyl-L-aspartateReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by MTR, SLC7A13, NAT8Lcytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• oxalic acidReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of chloride and methionine (cytosol to extracellular)
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by MTR, SLC6A14, SLC26A6cytosol, extracellular space

• L-glutamic 5-semialdehydeReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. L-Ornithine:2-oxo-acid aminotransferase

  Catalysed by MTR, SLC7A6, OATcytosol, extracellular space, mitochondrial matrix

• anilineReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by MTR, NAGS, NAT2, NAT1cytosol, mitochondrial matrix

• CHEBI:17312Reach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by MTR, NAGScytosol, mitochondrial matrixOne of 2 routes

• 5'-deoxyadenosineReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by MTR, CDKAL1, CDK5RAP1cytosolOne of 4 routes

• CHEBI:17380Reach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by MTR, SLC7A5cytosol, extracellular spaceOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of methionine and proline (cytosol to extracellular)
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by MTR, SLC7A5, PRODH2cytosol, extracellular spaceOne of 2 routes

• agmatineReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of arginine and methionine (cytosol to extracellular)
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by MTR, SLC7A6cytosol, extracellular space, mitochondrial matrix

• 5-aminolevulinic acidReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by MTR, SLC7A5, ALAS1, ALAS2 and 1 morecytosol, extracellular space, mitochondrial matrix

• indole-3-pyruvateReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by MTR, SLC7A5, IL4I1cytosol, extracellular spaceOne of 2 routes

• 3,3',5'-triiodo-L-thyronine sulfateReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 3,3',5'-triiodo-L-thyronine sulfate + iodide + A + H(+) = L-thyroxine sulfate + AH2

  Catalysed by MTR, CDKAL1, DIO1cytosol

• 3,3'-diiodo-L-thyronineReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2

  Catalysed by MTR, CDKAL1, DIO1, DIO3cytosolOne of 2 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2

  Catalysed by MTR, CDKAL1, DIO1cytosolOne of 2 routes