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Proteins/UNIPROT:Q96SZ6
Methylthiotransferase that catalyzes the conversion of N6-(dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp). Essential for efficient and highly accurate protein translation by the ribosome. Specifically inhibits CDK5 activation by CDK5R1. Essential for efficient mitochondrial protein synthesis and respiratory chain; shows pathological consequences in mitochondrial disease..
Function from UniProtKB (Q96SZ6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
20 statements
20 statements · 5 reference databases · Subject: CDK5RAP1 · Sources: gene ontology, Hetionet, Rhea, UniProt, WikiPathways
1 reaction
CHEBI:74415+CHEBI:29917+AH2+2S-adenosyl-L-methionineCHEBI:74417+CHEBI:64428+5'-deoxyadenosine+L-methionine+A+S-adenosyl-L-homocysteine+2hydron
Catalysed by CDK5RAP1
Reaction pageLeft to rightBalanced
Rhea RHEA:37067CC BY 4.0Reference data
5 names
Resolves to: CDK5RAP1