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Proteins/UNIPROT:Q99707
Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine..
Function from UniProtKB (Q99707), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
58 statements
58 statements · 6 reference databases · Subject: MTR · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
3 reactions
5-methyltetrahydrofolic acid+homocysteineproton+L-methionine+5,6,7,8-tetrahydrofolic acid
Catalysed by MTR
Reaction pageLeft to rightBalancedEC 2.1.1.13cytosol
Human-GEM MAR03917CC BY 4.0Reference data
MAM01114c+Se-methylselenocysteineselenomethionine+MAM02979c
Catalysed by MTR
Reaction pageLeft to rightBalancedEC 2.1.1.13cytosol
4 names
Resolves to: MTR
Human-GEM MAR09575CC BY 4.0Reference data
(6S)-5-methyl-5,6,7,8-tetrahydrofolate+L-homocysteine(6S)-5,6,7,8-tetrahydrofolate+L-methionine
Catalysed by MTR
Reaction pageLeft to rightBalanced
Rhea RHEA:11172CC BY 4.0Reference data