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Proteins/UNIPROT:P04818
Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the mitochondrial and nuclear de novo thymidylate biosynthesis pathway..
Function from UniProtKB (P04818), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1,016 statements
1,016 statements · 8 reference databases · Subject: TYMS · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
2 reactions
(6R)-5,10-methylenetetrahydrofolic acid+dUMP7,8-dihydrofolate+dTMP
Catalysed by TYMS
Reaction pageLeft to rightBalancedEC 2.1.1.45cytosol
Human-GEM MAR04644CC BY 4.0Reference data
dUMP+(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate7,8-dihydrofolate+dTMP
Catalysed by TYMS
Reaction pageLeft to rightBalanced
2 names
Resolves to: TYMS