glycodeoxycholate

Three steps

• 11-cis-retinolReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by BAAT, DGAT1, LRAT, AWAT1 and 2 morecytosol, peroxisome

• (R)-3-aminoisobutyric acidReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of alanine and glycine (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC3A2, SLC7A5, SLC7A10, AGXT2cytosol, extracellular space, mitochondrial matrix

• lithocholic acidReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and lithocholate (cytosol to extracellular)

  Catalysed by GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• iodideReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of chloride and iodide (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, SLC26A4cytosol, extracellular spaceOne of 3 routes

• oxaloacetateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. bile acid-CoA: amino acid N-acyltransferase
  3. ATP citrate lyase (citrate)

  Catalysed by BAAT, ACLYcytosol, peroxisome

• nitric oxideReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of arginine and glycine (cytosol to extracellular)
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by SLC7A6, NOS3, NOS1, NOS2cytosol, extracellular spaceOne of 2 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by GATM, ACY1cytosol

• 2-phenylacetamideReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by SLC7A5, EPXcytosol, extracellular space

• D-alanyl-D-alanineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of D-alanine and glycine (cytosol to extracellular)
  3. Formation of Alanylalanine

  Catalysed by SLC3A2, SLC7A10cytosol, extracellular space

• CHEBI:16633Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of alanine and glycine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC3A2, SLC7A5, SLC7A10, SCLYcytosol, extracellular space

• Met-tRNA(Met)Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by SLC7A5, MARS1cytosol, extracellular space

• (S)-lactateReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. urate(out) + (S)-lactate(in) = urate(in) + (S)-lactate(out)

  Catalysed by ABCC4, SLC22A13, SLC22A12inner side of the membrane, outer side of the membrane

• taurochenodeoxycholate 3-sulfateReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. taurochenodeoxycholate + 3'-phosphoadenylyl sulfate = taurochenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by ABCC4, SULT2A1inner side of the membrane, outer side of the membrane

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by SLC7A5, AADATcytosol, extracellular spaceOne of 2 routes

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by SLC7A5, CNDP2cytosol, extracellular space

• 2-oxobutanoateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of glycine and threonine (cytosol to extracellular)
  3. L-threonine ammonia-lyase (2-oxobutanoate-forming)

  Catalysed by SLC3A2, SLC7A5, SLC7A10, SDS and 1 morecytosol, extracellular spaceOne of 5 routes

• tryptamineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. L-tryptophan decarboxy-lyase

  Catalysed by SLC7A5, DDCcytosol, extracellular space

• 2-oxoglutaramateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by SLC7A5, KYAT1cytosol, extracellular spaceOne of 3 routes

• formaldehydeReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. S-Adenosyl-L-methionine:glycine N-methyltransferase
  3. sarcosine:oxygen oxidoreductase (demethylating)

  Catalysed by GNMT, PIPOX, SARDHcytosol, peroxisomeOne of 3 routes

• creatineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. S-Adenosyl-L-methionine:guanidinoacetate N-methyltransferase

  Catalysed by GATM, GAMTcytosolOne of 2 routes

• ferrocytochrome cReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. sulfite:ferricytochrome-c oxidoreductase

  Catalysed by ABCC4, TSTD1, SUOXinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• bilirubin IXalphaReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of bilirubin and GSH (cytosol to extracellular)

  Catalysed by GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• oxalic acidReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycine:oxygen oxidoreductase (deaminating)
  3. Glyoxylate:oxygen oxidoreductase

  Catalysed by DAO, HAO1cytosol, peroxisomeOne of 3 routes

• (R)-lactaldehydeReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. (R)-S-lactoylglutathione = methylglyoxal + glutathione
  3. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)

  Catalysed by ABCC4, GLO1, ADH1C, ADH1A and 5 moreinner side of the membrane, outer side of the membrane, cytosol

• taurolithocholateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and taurolithocholate (cytosol to extracellular)

  Catalysed by GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• CHEBI:17208Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. glutathione:dehydroascorbate oxidoreductase

  Catalysed by GSScytosolOne of 2 routes

• homocysteineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. Formation of Homocystine

  Catalysed by GSScytosol

• L-glutamic 5-semialdehydeReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. L-Ornithine:2-oxo-acid aminotransferase

  Catalysed by GATM, OATcytosol, mitochondrial matrix

• anilineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by BAAT, NAT2, NAT1cytosol, peroxisome

• CHEBI:17312Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. bile acid-CoA: amino acid N-acyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by BAATcytosol, peroxisomeOne of 2 routes

• CHEBI:17380Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by SLC7A5cytosol, extracellular spaceOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of glycine and proline (cytosol to extracellular)
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by SLC7A5, SLC7A6, PRODH2cytosol, extracellular spaceOne of 2 routes

• agmatineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of arginine and glycine (cytosol to extracellular)
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by SLC7A6cytosol, extracellular space, mitochondrial matrix

• AH2Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of alanine and glycine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by SLC3A2, SLC7A5, SLC7A10, MOCOScytosol, extracellular spaceOne of 4 routes

• indole-3-pyruvateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by SLC7A5, IL4I1cytosol, extracellular spaceOne of 3 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by BAAT, HADHA, ACADVL, HADHBcytosol, peroxisome, mitochondrial matrix

• xanthineReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. xanthine + NAD(+) + H2O = urate + NADH + H(+)

  Catalysed by ABCC4, SLC22A13, XDHinner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:17724Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. S-Adenosyl-L-methionine:glycine N-methyltransferase
  3. dimethylglycine dehydrogenase (formaldehyde)

  Catalysed by GNMT, PDPR, DMGDHcytosol

• Ala-tRNA(Ala)Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of alanine and glycine (cytosol to extracellular)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC3A2, SLC7A5, SLC7A10, AARS1cytosol, extracellular space

• glycine betaineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, SLC6A12cytosol, extracellular spaceOne of 3 routes

• trans-urocanateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of glycine and histidine (cytosol to extracellular)
  3. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by SLC7A6, HALcytosol, extracellular space

• 5-hydroxy-L-tryptophanReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by SLC7A5, TPH1, TPH2cytosol, extracellular space

• 4-methyl-2-oxopentanoateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of glycine and leucine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC7A5, BCAT2cytosol, extracellular space, mitochondrial matrixOne of 5 routes

• CHEBI:17927Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. bile acid-CoA: amino acid N-acyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by BAATcytosol, peroxisomeOne of 2 routes

• 3-phenylpyruvateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. Phenylalanine Transaminase, Mitochondrial

  Catalysed by SLC7A5, GOT2, TATcytosol, extracellular space, mitochondrial matrixOne of 6 routes

• fumaric acidReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. transport of fumarate and sulfite (cytosol to mitochondria)

  Catalysed by ABCC4, TSTD1, SLC25A10inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• 5-hydroxyisourateReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. urate:oxygen oxidoreductase

  Catalysed by ABCC4, SLC22A13inner side of the membrane, outer side of the membrane, cytosol

• CHEBI:18095Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, CLTRN, SLC6A20cytosol, extracellular spaceOne of 5 routes

• N-carbamoyl-beta-alanineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of chloride and glycine (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by SLC6A9, SLC6A14cytosol, extracellular spaceOne of 2 routes

• N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)
  3. 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase

  Catalysed by GARTcytosol