(R)-lactaldehyde

1. aldose reductase (D-lactaldehyde)

Catalysed by AKR7A2, AKR1A1, AKR1B1cytosol

1. Lactaldehyde Dehydrogenase, Mitochondrial

Catalysed by ALDH2, ALDH4A1, ALDH1B1, ALDH5A1 and 2 moremitochondrial matrixOne of 2 routes

1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)

Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 3 morecytosol

1. Lactaldehyde Dehydrogenase, Mitochondrial
2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase

Catalysed by ALDH2, ALDH4A1, ALDH1B1, ALDH5A1 and 3 moremitochondrial matrix, cytosolOne of 2 routes

1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
2. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)

Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 4 more

1. Lactaldehyde Dehydrogenase, Mitochondrial
2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
3. transport of 2-hydroxybutyrate and pyruvate (cytosol to extracellular)

Catalysed by ALDH2, ALDH4A1, ALDH1B1, ALDH5A1 and 9 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
2. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
3. cumene hydroperoxide + 2 glutathione = 2-phenylpropan-2-ol + glutathione disulfide + H2O