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Proteins/UNIPROT:P47989

XDH

Protein·UNIPROT:P47989Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase

Open in the graph

Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro)..

Function from UniProtKB (P47989), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

xanthinuria type I has a germline basis in XDHDiseaseGenCC HGNC:12805|MONDO:0010209Inferred only

Statements

37 statements

37 statements · 7 reference databases · Subject: XDH · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

Search this listOrder

XDH is expressed in ileal mucosaAnatomyBgee ENSG00000158125Inferred only
XDH is expressed in jejunal mucosaAnatomyBgee ENSG00000158125Inferred only
BTN1A1 interacts with XDHProteinHetionet hetionet:interacts:696-7498Inferred only
UBC interacts with XDHProteinHetionet hetionet:interacts:7316-7498Inferred only
hypoxanthine is metabolised by XDHCompoundHuman-GEM MAR04519Inferred only
hypoxanthine is metabolised by XDHCompoundRhea RHEA:24670Inferred only
hypoxanthine is metabolised by XDHCompoundHuman-GEM MAR08755Inferred only
hypoxanthine is metabolised by XDHCompoundHuman-GEM MAR04520Inferred only
urate is metabolised by XDHCompoundRhea RHEA:21132Inferred only
urate is metabolised by XDHCompoundRhea RHEA:16669Inferred only
xanthine is metabolised by XDHCompoundHuman-GEM MAR04648Inferred only
xanthine is metabolised by XDHCompoundRhea RHEA:21132Inferred only

Show the remaining 25

xanthine is metabolised by XDHCompoundRhea RHEA:16669Inferred only
xanthine is metabolised by XDHCompoundHuman-GEM MAR04646Inferred only
xanthine is metabolised by XDHCompoundHuman-GEM MAR04650Inferred only
xanthine is metabolised by XDHCompoundHuman-GEM MAR04649Inferred only
xanthine is metabolised by XDHCompoundRhea RHEA:24670Inferred only
XDH participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
XDH participates in Azathioprine ADMEPathwayReactome R-HSA-9748787Inferred only
XDH participates in Butyrophilin (BTN) family interactionsPathwayReactome R-HSA-8851680Inferred only
XDH participates in Caffeine and theobromine metabolismPathwayWikiPathways WP3633Inferred only
XDH participates in Drug ADMEPathwayReactome R-HSA-9748784Inferred only
XDH participates in Effects of nitric oxidePathwayWikiPathways WP1995Inferred only
XDH participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
XDH participates in Metabolic epileptic disordersPathwayWikiPathways WP5355Inferred only
XDH participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
XDH participates in Metabolism of nucleotidesPathwayReactome R-HSA-15869Inferred only
XDH participates in Molybdenum cofactor Moco biosynthesisPathwayWikiPathways WP4507Inferred only
XDH participates in Nucleotide catabolismPathwayReactome R-HSA-8956319Inferred only
XDH participates in Oxidative stress responsePathwayWikiPathways WP408Inferred only
XDH participates in Purine catabolismPathwayReactome R-HSA-74259Inferred only
XDH participates in Purine metabolismPathwayWikiPathways WP4792Inferred only
XDH participates in Purine metabolism and related disordersPathwayWikiPathways WP4224Inferred only
XDH participates in Selenium micronutrient networkPathwayWikiPathways WP15Inferred only
XDH requires the cofactor di-mu-sulfido-diironCompoundUniProt P47989Inferred only
XDH requires the cofactor FAD(3-)CompoundUniProt P47989Inferred only
XDH requires the cofactor Mo-molybdopterinCompoundUniProt P47989Inferred only

Reactions

12 reactions

water+hypoxanthine+NAD(+)proton+NADH(2-)+xanthine
Catalysed by XDH
Reaction pageLeft to rightBalancedEC 1.17.1.4cytosol
Human-GEM MAR04519CC BY 4.0Reference data
water+hypoxanthine+dioxygenhydrogen peroxide+xanthine
Catalysed by

Other names

6 names

Resolves to: XDH

Also called: ]Xanthine oxidoreductaseXDXDHAXOXOR

← Every protein Find it in the graph →

Reaction pageLeft to rightBalancedEC 1.17.3.2cytosol

Human-GEM MAR04520CC BY 4.0Reference data

water+NAD(+)+xanthineproton+NADH(2-)+urate

Catalysed by XDH

Reaction pageLeft to rightBalancedEC 1.17.1.4cytosol

Human-GEM MAR04646CC BY 4.0Reference data

water+NAD(+)+xanthineproton+NADH(2-)+urate

Catalysed by XDH

Reaction pageLeft to rightBalancedEC 1.17.1.4peroxisome

Human-GEM MAR04648CC BY 4.0Reference data

water+dioxygen+xanthinehydrogen peroxide+urate

Catalysed by XDH

Reaction pageLeft to rightBalancedEC 1.17.3.2cytosol

Human-GEM MAR04649CC BY 4.0Reference data

FAD+water+xanthineFADH2+urate

Catalysed by XDH

Reaction pageLeft to rightBalancedEC 1.17.3.2peroxisome

Human-GEM MAR04650CC BY 4.0Reference data

FAD+water+hypoxanthineFADH2+xanthine

Catalysed by XDH

Reaction pageLeft to rightBalancedEC 1.17.3.2peroxisome

Human-GEM MAR08755CC BY 4.0Reference data

water+dioxygen+MAM03418chydrogen peroxide+MAM03801c

Catalysed by AOX1 or XDH

Reaction pageLeft to rightBalancedEC 1.17.3.2, 1.2.3.1cytosol

Human-GEM MAR12472CC BY 4.0Reference data

FADH2+dioxygenFAD+hydrogen peroxide

Catalysed by ACOX1 or ACOX2 or ACOX3 or DAO or DDO or NOS2 or PAOX or PIPOX or XDH

Reaction pageLeft to rightBalancedperoxisome

Human-GEM MAR20114CC BY 4.0Reference data

xanthine+NAD(1-)+waterurate+NADH(2-)+hydron

Catalysed by XDH

Reaction pageDirection not assertedBalanced

Rhea RHEA:16669CC BY 4.0Reference data

xanthine+dioxygen+waterurate+hydrogen peroxide

Catalysed by XDH

Reaction pageDirection not assertedBalanced

Rhea RHEA:21132CC BY 4.0Reference data

hypoxanthine+NAD(1-)+waterxanthine+NADH(2-)+hydron

Catalysed by XDH

Reaction pageDirection not assertedBalanced

Rhea RHEA:24670CC BY 4.0Reference data