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Proteins/UNIPROT:Q9UI17
Catalyzes the demethylation of N,N-dimethylglycine to sarcosine. Also has activity with sarcosine in vitro..
Function from UniProtKB (Q9UI17), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
18 statements
18 statements · 8 reference databases · Subject: DMGDH · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
4 reactions
formaldehyde+proton+NADPH(4-)+CHEBI:15611CHEBI:17724+water+NADP(3-)
Reaction pageReversibleBalancedEC 1.5.8.4cytosol
Human-GEM MAR04700CC BY 4.0Reference data
1 name
Resolves to: DMGDH
Reaction pageLeft to rightBalancedEC 1.5.8.4cytosol
Human-GEM MAR04701CC BY 4.0Reference data
CHEBI:17724+FAD+waterFADH2+formaldehyde+CHEBI:15611
Catalysed by DMGDH
Reaction pageLeft to rightBalancedEC 1.5.8.4mitochondrial matrix
Human-GEM MAR08439CC BY 4.0Reference data
(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n)+N,N-dimethylglycine+oxidized [electron-transfer flavoprotein]+hydron(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)+sarcosine+reduced [electron-transfer flavoprotein]
Catalysed by DMGDH
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:52856CC BY 4.0Reference data