citric acid

Three steps

• CHEBI:15345Reach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by ACLY, CS, AACScytosol, mitochondrial matrixOne of 2 routes

• cholineReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. transport of chloride and choline (cytosol to extracellular)

  Catalysed by SLC25A1, SLC26A6, SLC5A7mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• acetylpyruvateReach from here →
  1. Citrate Transport, Mitochondrial
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. acetylpyruvate + H2O = acetate + pyruvate + H(+)

  Catalysed by SLC25A1, ME2, ME3, FAHD1mitochondrial matrix, cytosol

• all-trans-retinoic acidReach from here →
  1. Citrate Transport, Mitochondrial
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. transport of pyruvate and retinoate (cytosol to extracellular)

  Catalysed by SLC25A1, ME2, ME3, SLC16A4 and 5 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• CHEBI:15380Reach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by ACLY, CS, ALAS1, CPNE7cytosol, mitochondrial matrixOne of 8 routes

• CHEBI:15477Reach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by ACLY, CS, GLYAT, GLYATL2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Production of Tiglylcarnitine

  Catalysed by ACLY, CS, CPT1A, CPT1Bcytosol, mitochondrial matrixOne of 2 routes

• isobutyryl-CoAReach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by ACLY, CS, HADHA, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by ACLY, CS, GLYATcytosol, mitochondrial matrix

• isovaleryl-CoAReach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by ACLY, CS, GLYAT, GLYATL2 and 1 morecytosol, mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by ACLY, CS, SLC27A2, ACSL4 and 6 morecytosol, mitochondrial matrixOne of 11 routes

• CHEBI:15519Reach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. propanoyl-CoA C-acyltransferase

  Catalysed by ACLY, CS, ACAA1, SCP2 and 1 morecytosol, mitochondrial matrix, peroxisomeOne of 2 routes

• palmitoyl-CoAReach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by ACLY, CS, SLC27A2, ACSL4 and 6 morecytosol, mitochondrial matrixOne of 11 routes

• oleoyl-CoAReach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by ACLY, CS, CPT1A, CPT1C and 1 morecytosol, mitochondrial matrixOne of 11 routes

• phenylacetyl-CoAReach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Phenylacetate:CoA ligase

  Catalysed by ACLY, CScytosol, mitochondrial matrixOne of 3 routes

• propionyl-CoAReach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by ACLY, CS, ACSS3, ACSS2 and 1 morecytosol, mitochondrial matrixOne of 43 routes

• L-leucineReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. transport of chloride and leucine (cytosol to extracellular)

  Catalysed by SLC25A1, SLC26A6, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• CHEBI:15650Reach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by ACLY, CS, ZDHHC11B, NAA10 and 30 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:15727Reach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by ACLY, CS, NAA10cytosol, mitochondrial matrix

• CHEBI:15746Reach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by ACLY, CS, SAT1, SAT2cytosol, mitochondrial matrixOne of 2 routes

• N-carbamoyl-L-aspartic acidReach from here →
  1. ATP citrate lyase (citrate)
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by ACLY, GOT2, CADcytosol, mitochondrial matrix

• alpha-D-glucosamine 6-phosphateReach from here →
  1. transport of citrate and PEP (cytosol to mitochondria)
  2. dATP:pyruvate 2-O-phosphotransferase
  3. dATP:D-glucosamine 6-phosphotransferase

  Catalysed by SLC25A1, PKM, PKLR, HK1 and 2 moremitochondrial matrix, cytosol

• keto-D-fructose 6-phosphateReach from here →
  1. transport of citrate and PEP (cytosol to mitochondria)
  2. dATP:pyruvate 2-O-phosphotransferase
  3. dATP:D-fructose 6-phosphotransferase

  Catalysed by SLC25A1, PKM, PKLR, HK1 and 3 moremitochondrial matrix, cytosol

• CHEBI:15971Reach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. transport of chloride and histidine (cytosol to extracellular)

  Catalysed by SLC25A1, SLC26A6, SLC6A14mitochondrial matrix, cytosol, extracellular space

• CHEBI:16174Reach from here →
  1. transport of citrate and PEP (cytosol to mitochondria)
  2. dATP:pyruvate 2-O-phosphotransferase
  3. ATP:dADP phosphotransferase

  Catalysed by SLC25A1, PKM, PKLR, NME4 and 4 moremitochondrial matrix, cytosolOne of 20 routes

• 2-methyl-3-oxopropanoic acidReach from here →
  1. Citrate Transport, Mitochondrial
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC25A1, ME2, ME3, AGXT2mitochondrial matrix, cytosol

• L-cystineReach from here →
  1. ATP citrate lyase (citrate)
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)

  Catalysed by ACLY, GOT2, SLC7A13cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• 11-cis-retinolReach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by ACLY, CS, DGAT1, LRAT and 3 morecytosol, mitochondrial matrix

• iodideReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. transport of chloride and iodide (cytosol to extracellular)

  Catalysed by SLC25A1, SLC26A6, SLC26A4mitochondrial matrix, cytosol, extracellular space

• ubiquinonesReach from here →
  1. Citrate Transport, Mitochondrial
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. succinate:quinone oxidoreductase

  Catalysed by SLC25A1, FH, SDHD, SDHB and 2 moremitochondrial matrix, cytosol

• L-valineReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. transport of chloride and valine (cytosol to extracellular)

  Catalysed by SLC25A1, SLC26A6, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• L-arginineReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by SLC25A1, SLC26A6, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• protein polypeptide chainReach from here →
  1. ATP citrate lyase (citrate)
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. PROTEIN_BS

  Catalysed by ACLY, GOT2cytosol, mitochondrial matrix

• (S)-lactateReach from here →
  1. Citrate Transport, Mitochondrial
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by SLC25A1, ME2, ME3, LDHA and 4 moremitochondrial matrix, cytosol

• quinolinic acidReach from here →
  1. Citrate Transport, Mitochondrial
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Transport of Quinolinic Acid

  Catalysed by SLC25A1, SLC25A10, SLC22A6mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. Citrate Transport, Mitochondrial
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by SLC25A1, CLYBL, AADATmitochondrial matrix, cytosol

• 2-oxobutanoateReach from here →
  1. Citrate Transport, Mitochondrial
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by SLC25A1, ME2, ME3, AGXT2mitochondrial matrix, cytosolOne of 3 routes

• 2-oxoglutaramateReach from here →
  1. Citrate Transport, Mitochondrial
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by SLC25A1, ME2, ME3, KYAT1mitochondrial matrix, cytosolOne of 2 routes

• 3-fumarylpyruvateReach from here →
  1. Citrate Transport, Mitochondrial
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by SLC25A1, ME2, ME3, FAHD1mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:16857Reach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Transport of L-Threonine by Atb0 Transporter

  Catalysed by SLC25A1, SLC26A6, SLC6A14mitochondrial matrix, cytosol, extracellular space

• glyoxylic acidReach from here →
  1. ATP citrate lyase (citrate)
  2. D-aspartate:2-oxoglutarate aminotransferase
  3. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)

  Catalysed by ACLY, GOT2, HOGA1cytosol, mitochondrial matrix

• ferrocytochrome cReach from here →
  1. Citrate Transport, Mitochondrial
  2. transport of malate and sulfite (cytosol to mitochondria)
  3. sulfite:ferricytochrome-c oxidoreductase

  Catalysed by SLC25A1, SLC25A10, SUOXmitochondrial matrix, cytosol

• N-acetyl-L-aspartateReach from here →
  1. ATP citrate lyase (citrate)
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by ACLY, GOT2, NAT8Lcytosol, mitochondrial matrixOne of 2 routes

• (R)-3-hydroxybutyric acidReach from here →
  1. Citrate Transport, Mitochondrial
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. transport of (R)-3-hydroxybutanoate and pyruvate (cytosol to extracellular)

  Catalysed by SLC25A1, ME2, ME3, SLC16A4 and 5 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• 3-hydroxypyruvateReach from here →
  1. Citrate Transport, Mitochondrial
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by SLC25A1, ME2, ME3, AGXTmitochondrial matrix, cytosol

• L-isoleucineReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. transport of chloride and isoleucine (cytosol to extracellular)

  Catalysed by SLC25A1, SLC26A6, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• CHEBI:17203Reach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Transport of L-Proline by the Apical Imino Amino Acid Transporters

  Catalysed by SLC25A1, SLC26A6, CLTRN, SLC6A20mitochondrial matrix, cytosol, extracellular spaceOne of 3 routes

• anilineReach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by ACLY, CS, NAT2, NAT1cytosol, mitochondrial matrix

• aceneuramateReach from here →
  1. Citrate Transport, Mitochondrial
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by SLC25A1, ME2, ME3, NPLmitochondrial matrix, cytosol

• CHEBI:17312Reach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by ACLY, CScytosol, mitochondrial matrixOne of 2 routes