a dicarboxylate

Three steps

• cholateReach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. solute carrier organic anion transporter (cholate)

  Catalysed by SLC22A6, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 5 routes

• hydrogen sulfideReach from here →
  1. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by SLC22A6, SLC22A13, TSTD1inner side of the membrane, outer side of the membraneOne of 3 routes

• acetateReach from here →
  1. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  2. transport of L-lactate and urate (cytosol to extracellular)
  3. transport of acetate and L-lactate (cytosol to extracellular)

  Catalysed by SLC22A6, SLC22A12, SLC16A4, SLC16A5 and 4 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• formic acidReach from here →
  1. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  2. transport of L-lactate and urate (cytosol to extracellular)
  3. transport of formate and L-lactate (cytosol to extracellular)

  Catalysed by SLC22A6, SLC22A12, SLC16A4, SLC16A5 and 4 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• propionic acidReach from here →
  1. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  2. transport of L-lactate and urate (cytosol to extracellular)
  3. transport of L-lactate and propanoate (cytosol to extracellular)

  Catalysed by SLC22A6, SLC22A12, SLC16A4, SLC16A5 and 4 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• citric acidReach from here →
  1. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Citrate Transport, Mitochondrial

  Catalysed by SLC25A35, SLC25A34, SLC25A10, SLC25A1inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 10 routes

• butyric acidReach from here →
  1. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  2. transport of L-lactate and urate (cytosol to extracellular)
  3. transport of butyrate and L-lactate (cytosol to extracellular)

  Catalysed by SLC22A6, SLC22A12, SLC16A4, SLC16A5 and 4 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• adipic acidReach from here →
  1. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. hexanedioate + glutaryl-CoA = hexanedioyl-CoA + glutarate

  Catalysed by SLC22A8, SLC22A6, SUGCTinner side of the membrane, outer side of the membrane

• orotateReach from here →
  1. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  2. nicotinate(in) + urate(out) = nicotinate(out) + urate(in)
  3. orotate(out) + nicotinate(in) = orotate(in) + nicotinate(out)

  Catalysed by SLC22A6, SLC22A12, SLC22A13inner side of the membrane, outer side of the membraneOne of 2 routes

• an alcoholReach from here →
  1. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by SLC22A6, SLC22A13, CP, PRDX6inner side of the membrane, outer side of the membrane

• isocitric acidReach from here →
  1. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SLC25A35, SLC25A34, SLC25A10, SLC25A1inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 6 routes

• pentanoateReach from here →
  1. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. pentanoate(out) + dehydroepiandrosterone 3-sulfate(in) = pentanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by SLC25A35, SLC25A34, STS, SLC22A9inner side of the membrane, outer side of the membraneOne of 4 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of arachidonate (cytosol to extracellular)

  Catalysed by SLC22A6, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• cis-aconitic acidReach from here →
  1. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SLC25A35, SLC25A34, SLC25A10, SLC25A1inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 6 routes

• N-carbamoyl-L-aspartateReach from here →
  1. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by SLC25A35, SLC25A34, SLC25A14, SLC25A30 and 1 moreinner side of the membrane, outer side of the membrane

• a phenolReach from here →
  1. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  2. an aryl sulfate + H2O = a phenol + sulfate + H(+)
  3. an aryl sulfate + H2O = a phenol + sulfate + H(+)

  Catalysed by SLC25A35, SLC25A34, ARSL, ARSF and 4 moreinner side of the membrane, outer side of the membrane

• serotoninReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  3. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2

  Catalysed by SLC22A6, SLC22A8, TPH1, TPH2 and 1 moreinner side of the membrane, outer side of the membraneOne of 5 routes

• 5-aminolevulinateReach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by SLC22A6, SLC22A8, GLYAT, ALAS1 and 1 moreinner side of the membrane, outer side of the membrane

• chenodeoxycholateReach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. solute carrier organic anion transporter (chenodiol)

  Catalysed by SLC22A6, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate

  Catalysed by SLC22A6, SLC22A8, PAH, TATinner side of the membrane, outer side of the membraneOne of 3 routes

• glycochenodeoxycholateReach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by SLC22A6, SLC22A8, GLYAT, BAATinner side of the membrane, outer side of the membraneOne of 2 routes

• taurocholateReach from here →
  1. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. taurocholate(out) + glutarate(in) = taurocholate(in) + glutarate(out)

  Catalysed by SLC22A8, SLC22A6, SLC22A24inner side of the membrane, outer side of the membraneOne of 7 routes

• glycochenodeoxycholic acidReach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SLC22A6, SLC22A8, GLYAT, BAATinner side of the membrane, outer side of the membrane, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by SLC22A6, SLC22A8, GLYAT, AADATinner side of the membrane, outer side of the membraneOne of 12 routes

• glycolithocholic acidReach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by SLC22A6, SLC22A8, GLYAT, BAATinner side of the membrane, outer side of the membrane, cytosolOne of 6 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by SLC22A6, SLC22A8, GLYAT, GCATinner side of the membrane, outer side of the membrane, mitochondrial matrix

• tert-butanolReach from here →
  1. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

  Catalysed by SLC22A6, SLC22A13, CLIC2, GPX1 and 3 moreinner side of the membrane, outer side of the membrane

• L-ornithineReach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. L-Arginine:glycine amidinotransferase

  Catalysed by SLC22A6, SLC22A8, GLYAT, GATMinner side of the membrane, outer side of the membrane, cytosolOne of 5 routes

• (5-hydroxyindol-3-yl)acetaldehydeReach from here →
  1. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  2. Transport of 5-Hydroxyindoleacetate
  3. (5-hydroxyindol-3-yl)acetaldehyde + NAD(+) + H2O = (5-hydroxyindol-3-yl)acetate + NADH + 2 H(+)

  Catalysed by SLC25A35, SLC25A34, SLC4A1, ALDH9A1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• gamma-Glu-AlaReach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by SLC22A6, SLCO2A1, GGT1, GGT5 and 4 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by SLC22A6, SLC22A8, GLYAT, GLDC and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix

• taurineReach from here →
  1. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3

  Catalysed by SLC25A35, SLC25A34, SLC26A6, SLC6A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 3,3',5-triiodo-L-thyronineReach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLC22A6, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• malonaldehydeReach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. prostaglandin-F synthase (prostaglandin F2alpha)
  3. thromboxane A synthase (12(S)-HHT)

  Catalysed by SLC22A6, TBXAS1inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• (S)-malyl-CoAReach from here →
  1. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate

  Catalysed by SLC25A35, SLC25A34, SLC25A10, SUCLG1 and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• glutaryl-CoAReach from here →
  1. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. glutarate + succinyl-CoA = glutaryl-CoA + succinate

  Catalysed by SLC22A8, SLC22A6, SUGCTinner side of the membrane, outer side of the membraneOne of 4 routes

• prostaglandin E1Reach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of prostaglandin E1 (cytosol to extracellular)

  Catalysed by SLC22A6, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 6 routes

• 13,14-dihydro-15-oxo-prostaglandin E2Reach from here →
  1. prostaglandin E2(out) + a dicarboxylate(in) = prostaglandin E2(in) + a dicarboxylate(out)
  2. prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)
  3. 13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) = 15-oxoprostaglandin E2 + NADPH + H(+)

  Catalysed by SLC22A6, HPGD, PTGR1, PTGR3 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin I2Reach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. prostaglandin-F synthase (prostaglandin F2alpha)
  3. prostaglandin I2 synthase (prostaglandin H2)

  Catalysed by SLC22A6, PTGISinner side of the membrane, outer side of the membrane, cytosol, endoplasmic reticulumOne of 7 routes

• 15-oxoprostaglandin D2Reach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. aldo-keto reductase (prostaglandin D2)
  3. 15-dehydro-prostaglandin D2 reduction

  Catalysed by SLC22A6, AKR1C3inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by SLC22A6, SLCO2A1, GPX5, GPX1 and 7 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• sarcosineReach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by SLC22A6, SLC22A8, GLYAT, PIPOXinner side of the membrane, outer side of the membraneOne of 2 routes

• thromboxane A2Reach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. prostaglandin-F synthase (prostaglandin F2alpha)
  3. thromboxane A synthase (prostaglandin H2)

  Catalysed by SLC22A6, TBXAS1inner side of the membrane, outer side of the membrane, cytosol, endoplasmic reticulumOne of 2 routes

• 7,8-dihydrofolateReach from here →
  1. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  2. Folate Transport by Oats
  3. dihydrofolate:NAD+ oxidoreductase

  Catalysed by SLC25A35, SLC25A34, SLC22A8, SLC22A7 and 2 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by SLC22A6, SLC22A8, GLYAT, SHMT1 and 1 moreinner side of the membrane, outer side of the membrane

• leukotriene A4Reach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of leukotriene A4 (cytosol to extracellular)

  Catalysed by SLC22A6, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• XMPReach from here →
  1. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  2. xanthine + NAD(+) + H2O = urate + NADH + H(+)
  3. XMP:pyrophosphate phosphoribosyltransferase

  Catalysed by SLC22A6, XDH, HPRT1inner side of the membrane, outer side of the membrane, cytosol

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by SLC25A35, SLC25A34, SLC25A10, ASLinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 4 routes

• (R)-S-lactoylglutathioneReach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
  3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by SLC22A6, SLCO2A1, GLO1, GLOD4inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• nicotinate beta-D-ribonucleotideReach from here →
  1. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  2. nicotinate(in) + urate(out) = nicotinate(out) + urate(in)
  3. 5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate

  Catalysed by SLC22A6, SLC22A12, SLC22A13, NAPRTinner side of the membrane, outer side of the membrane