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Reach

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A reference for what the literature reports. Not medical advice.

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XMP

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

24 compounds within 3 steps: 2 in 1, 6 in 2, 16 in 3

Does it reach a compound?

One step

xanthosineReach from here →
1. xanthosine 5'-phosphate phosphohydrolase
Catalysed by ACP3, NT5E, NT5C2, NT5C3B and 4 morecytosolOne of 2 routes
IMPReach from here →
1. IMP + NAD(+) + H2O = XMP + NADH + H(+)
Catalysed by IMPDH2, IMPDH1

Two steps

inosineReach from here →
1. IMP + NAD(+) + H2O = XMP + NADH + H(+)
2. IMP + H2O = inosine + phosphate
Catalysed by IMPDH2, IMPDH1, NT5E, NT5C2 and 2 moreOne of 7 routes
xanthineReach from here →
1. xanthosine 5'-phosphate phosphohydrolase
2. xanthosine:orthophosphate ribosyltransferase
Catalysed by ACP3, NT5E, NT5C2, NT5C3B and 5 morecytosol

Three steps

beta-nicotinamide D-ribosideReach from here →
Catalysed by ACP3, NT5E, NT5C2, NT5C3B and 5 morecytosol
CHEBI:16174Reach from here →
Catalysed by IMPDH2

D-ribose 1-phosphate

Reach from here →

xanthosine 5'-phosphate phosphohydrolase
xanthosine:orthophosphate ribosyltransferase

Catalysed by ACP3, NT5E, NT5C2, NT5C3B and 5 morecytosol

N(6)-(1,2-dicarboxyethyl)-AMPReach from here →

IMP + NAD(+) + H2O = XMP + NADH + H(+)
IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)

Catalysed by IMPDH2, IMPDH1, ADSS2, ADSS1

dGMPReach from here →

IMP + NAD(+) + H2O = XMP + NADH + H(+)
dGMP + inosine = 2'-deoxyguanosine + IMP

Catalysed by IMPDH2, IMPDH1, NT5C2

dIMPReach from here →

IMP + NAD(+) + H2O = XMP + NADH + H(+)
dIMP + inosine = 2'-deoxyinosine + IMP

Catalysed by IMPDH2, IMPDH1, NT5C2

mitochondrial matrix

adenosineReach from here →

xanthosine 5'-phosphate phosphohydrolase
xanthosine:orthophosphate ribosyltransferase
adenosine:phosphate alpha-D-ribosyltransferase

Catalysed by ACP3, NT5E, NT5C2, NT5C3B and 5 morecytosolOne of 4 routes

uridineReach from here →

xanthosine 5'-phosphate phosphohydrolase
xanthosine:orthophosphate ribosyltransferase
uridine:phosphate alpha-D-ribosyltransferase

Catalysed by ACP3, NT5E, NT5C2, NT5C3B and 7 morecytosolOne of 2 routes

guanosineReach from here →

xanthosine 5'-phosphate phosphohydrolase
xanthosine:orthophosphate ribosyltransferase
guanosine:phosphate alpha-D-ribosyltransferase

Catalysed by ACP3, NT5E, NT5C2, NT5C3B and 5 morecytosolOne of 2 routes

2'-deoxyguanosineReach from here →

IMP + NAD(+) + H2O = XMP + NADH + H(+)
IMP + H2O = inosine + phosphate
dGMP + inosine = 2'-deoxyguanosine + IMP

Catalysed by IMPDH2, IMPDH1, NT5E, NT5C2 and 2 moreOne of 6 routes

CHEBI:17202Reach from here →

IMP + NAD(+) + H2O = XMP + NADH + H(+)
IMP + H2O = inosine + phosphate
ATP:inosine 5'-phosphotransferase

Catalysed by IMPDH2, IMPDH1, NT5E, NT5C2 and 2 moremitochondrial matrixOne of 2 routes

hypoxanthineReach from here →

xanthosine 5'-phosphate phosphohydrolase
xanthosine:orthophosphate ribosyltransferase
hypoxanthine + NAD(+) + H2O = xanthine + NADH + H(+)

Catalysed by ACP3, NT5E, NT5C2, NT5C3B and 6 morecytosolOne of 3 routes

cytidineReach from here →

IMP + NAD(+) + H2O = XMP + NADH + H(+)
IMP + H2O = inosine + phosphate
inosine + CMP = cytidine + IMP

Catalysed by IMPDH2, IMPDH1, NT5E, NT5C2 and 2 more

urateReach from here →

xanthosine 5'-phosphate phosphohydrolase
xanthosine:orthophosphate ribosyltransferase
xanthine:NAD+ oxidoreductase

Catalysed by ACP3, NT5E, NT5C2, NT5C3B and 6 morecytosolOne of 6 routes

CHEBI:17797Reach from here →

xanthosine 5'-phosphate phosphohydrolase
xanthosine:orthophosphate ribosyltransferase
D-Ribose 1,5-phosphomutase

Catalysed by ACP3, NT5E, NT5C2, NT5C3B and 6 morecytosol

fumaric acidReach from here →

IMP + NAD(+) + H2O = XMP + NADH + H(+)
IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)

Catalysed by IMPDH2, IMPDH1, ADSS2, ADSS1 and 2 morecytosolOne of 2 routes

CHEBI:28862Reach from here →

IMP + NAD(+) + H2O = XMP + NADH + H(+)
dGMP + inosine = 2'-deoxyguanosine + IMP
ATP:dGMP phosphotransferase

Catalysed by IMPDH2, IMPDH1, NT5C2, GUK1cytosolOne of 2 routes

2'-deoxyinosineReach from here →

IMP + NAD(+) + H2O = XMP + NADH + H(+)
IMP + H2O = inosine + phosphate
dIMP + inosine = 2'-deoxyinosine + IMP

Catalysed by IMPDH2, IMPDH1, NT5E, NT5C2 and 2 moreOne of 4 routes

L-aspartateReach from here →

IMP + NAD(+) + H2O = XMP + NADH + H(+)
IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)

Catalysed by IMPDH2, IMPDH1, ADSS2, ADSS1

alpha-D-ribose 1-phosphateReach from here →

IMP + NAD(+) + H2O = XMP + NADH + H(+)
IMP + H2O = inosine + phosphate
inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine

Catalysed by IMPDH2, IMPDH1, NT5E, NT5C2 and 4 more