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Proteins/UNIPROT:Q16647
Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation. Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE)..
Function from UniProtKB (Q16647), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
75 statements
75 statements · 9 reference databases · Subject: PTGIS · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
5 reactions
prostaglandin H2prostaglandin I2
Catalysed by PTGIS
Reaction pageLeft to rightBalancedEC 5.3.99.4endoplasmic reticulum
Human-GEM MAR01308CC BY 4.0Reference data
prostaglandin H2prostaglandin I2
Catalysed by PTGIS
Reaction pageLeft to rightBalanced
Rhea RHEA:23580CC BY 4.0Reference data
(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate
4 names
Resolves to: PTGIS
Reaction pageLeft to rightBalanced
Rhea RHEA:48636CC BY 4.0Reference data
(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate+AH2(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate+A+water
Catalysed by TBXAS1 or PTGS2 or PTGIS
Reaction pageLeft to rightBalanced
Rhea RHEA:48856CC BY 4.0Reference data
CHEBI:59720CHEBI:131859+water
Catalysed by TBXAS1 or PTGIS or ALOXE3
Reaction pageLeft to rightBalanced
Rhea RHEA:55556CC BY 4.0Reference data