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Proteins/UNIPROT:Q6XQN6
Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis..
Function from UniProtKB (Q6XQN6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
45 statements
45 statements · 8 reference databases · Subject: NAPRT · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
2 reactions
proton+nicotinic acid+5-phospho-alpha-D-ribose 1-diphosphatenicotinic acid D-ribonucleotide+diphosphate(3-)
Catalysed by NAPRT
Reaction pageLeft to rightBalancedEC 6.3.4.21cytosol
Human-GEM MAR04254CC BY 4.0Reference data
5-phospho-alpha-D-ribose 1-diphosphate+nicotinate+ATP(4-)+waternicotinate beta-D-ribonucleotide+
5 names
Resolves to: NAPRT
Catalysed by NAPRT
Reaction pageDirection not assertedBalanced
Rhea RHEA:36163CC BY 4.0Reference data