Loading the page.
Proteins/UNIPROT:Q14914
NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha. Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (By similarity). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one. May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity)..
Function from UniProtKB (Q14914), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
58 statements
58 statements · 5 reference databases · Subject: PTGR1 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
20 reactions
MAM00307c+proton+NADH(2-)MAM00321c+NAD(+)
Catalysed by PTGR1 or HSD17B12 or TECRL
Reaction pageReversibleBalancedEC 1.3.1.-cytosol
Human-GEM MAR01074CC BY 4.0Reference data
12-oxo-leukotriene B4+proton+NADH(2-)MAM00253c+NAD(+)
Catalysed by PTGR1
8 names
Resolves to: PTGR1
Reaction pageLeft to rightBalancedEC 1.3.1.-cytosol
Human-GEM MAR01228CC BY 4.0Reference data
12-oxo-leukotriene B4+proton+NADH(2-)MAM00253m+NAD(+)
Catalysed by PTGR1 or HSD17B12 or TECRL
Reaction pageLeft to rightBalancedEC 1.3.1.-mitochondrial matrix
Human-GEM MAR01229CC BY 4.0Reference data
12-oxo-leukotriene B4+proton+NADH(2-)MAM00253x+NAD(+)
Catalysed by PTGR1 or HSD17B12 or TECRL
Reaction pageLeft to rightBalancedEC 1.3.1.-peroxisome
Human-GEM MAR01230CC BY 4.0Reference data
13,14-dihydro-15-oxo-prostaglandin E2+NADP(3-)15-oxoprostaglandin E2+NADPH(4-)+hydron
Catalysed by PTGR1 or PTGR3 or PTGR2
Reaction pageRight to leftBalanced
Rhea RHEA:11912CC BY 4.0Reference data
CHEBI:12834+NADP(3-)CHEBI:13757+NADPH(4-)+hydron
Catalysed by PTGR1
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:13737CC BY 4.0Reference data
CHEBI:133408+NADP(3-)15-oxoprostaglandin E1+NADPH(4-)+hydron
Catalysed by PTGR1 or PTGR3 or PTGR2
Reaction pageRight to leftBalanced
Rhea RHEA:50584CC BY 4.0Reference data
CHEBI:133374+NADP(3-)15-oxoprostaglandin F2alpha+NADPH(4-)+hydron
Catalysed by PTGR1 or PTGR3 or PTGR2
Reaction pageRight to leftBalanced
Rhea RHEA:50588CC BY 4.0Reference data
CHEBI:133411+NADP(3-)CHEBI:79072+NADPH(4-)+hydron
Catalysed by PTGR1 or PTGR3 or PTGR2
Reaction pageRight to leftBalanced
Rhea RHEA:50592CC BY 4.0Reference data
CHEBI:57461+NADP(3-)12-oxo-leukotriene B4+NADPH(4-)+hydron
Catalysed by PTGR1
Reaction pageLeft to rightBalanced
Rhea RHEA:50608CC BY 4.0Reference data
decanal+NADP(3-)CHEBI:133455+NADPH(4-)+hydron
Catalysed by PTGR1
Reaction pageRight to leftBalanced
Rhea RHEA:50612CC BY 4.0Reference data
CHEBI:77927+NADP(3-)CHEBI:133457+NADPH(4-)+hydron
Reaction pageRight to leftBalanced
Rhea RHEA:50616CC BY 4.0Reference data