Compound

thromboxane A2

An unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (RCS).

Definition from MeSH (D013928), National Library of Medicine, read 2026-09-23. NLM revises MeSH; this copy may not reflect its current record.

CHEBI:57445ChEBI

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Structure

2D depiction · 3D model shown

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A generated conformer of thromboxane A2 — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound, anion
Formula: C20H31O5
Mass: 351.463 g/mol
Charge: -1
InChIKey: DSNBHJFQCNUKMA-SCKDECHMSA-M
SMILES: CCCCC[C@H](O)/C=C/[C@H]1O[C@H]2C[C@H](O2)[C@@H]1C/C=CCCCC(=O)[O-]
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

2 entities

2 entities reached.

0 reported hops2 assembled from the scaffold

What the reference databases state

Statements

9 statements

9 statements · 2 reference databases · Subject: thromboxane A2 · Sources: Human-GEM, Rhea

Order

prostaglandin H2 is converted to thromboxane A2CompoundRhea RHEA:17137Inferred only
prostaglandin H2 is converted to thromboxane A2CompoundHuman-GEM MAR01313Inferred only
thromboxane A2 is converted to prostaglandin H2CompoundRhea RHEA:17137Inferred only
thromboxane B2 is converted to thromboxane A2CompoundHuman-GEM MAR10406Inferred only
thromboxane A2 is converted to thromboxane B2CompoundHuman-GEM MAR01315Inferred only
thromboxane A2 is converted to thromboxane B2CompoundHuman-GEM MAR10406Inferred only
thromboxane B2 is converted to thromboxane A2CompoundHuman-GEM MAR01315Inferred only
thromboxane A2 is metabolised by CYP2S1ProteinRhea RHEA:17137Inferred only
thromboxane A2 is a substrate of TBXAS1ProteinRhea RHEA:17137Inferred only

Reactions

9 reactions

prostaglandin H2thromboxane A2
Catalysed by TBXAS1
Reaction pageLeft to rightBalancedEC 5.3.99.5GO:0005783
Human-GEM MAR01313CC BY 4.0Reference data
water+thromboxane A2thromboxane B2
Reaction pageReversibleBalancedGO:0005783
Human-GEM MAR01315CC BY 4.0Reference data
thromboxane A2thromboxane A2
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR08854CC BY 4.0Reference data
thromboxane A2thromboxane A2
Reaction pageReversibleBalancedGO:0005829, GO:0005783
Human-GEM MAR08855CC BY 4.0Reference data
thromboxane A2
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR09433CC BY 4.0Reference data
water+thromboxane A2thromboxane B2
Reaction pageReversibleBalancedGO:0005829
Human-GEM MAR10406CC BY 4.0Reference data
prostaglandin H2thromboxane A2
Catalysed by TBXAS1 or CYP2S1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:17137CC BY 4.0Reference data
thromboxane A2+reduced [NADPH--hemoprotein reductase]+dioxygenCHEBI:137988+oxidized [NADPH--hemoprotein reductase]+water+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:53936CC BY 4.0Reference data
thromboxane A2+reduced [NADPH--hemoprotein reductase]+dioxygenCHEBI:137989+oxidized [NADPH--hemoprotein reductase]+water+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:53940CC BY 4.0Reference data

Other names

4 names

Resolves to: thromboxane A2

Also called: thromboxane A2 anionTXA2
Systematic name: (5Z,13E,15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dien-1-oate(5Z,13E,15S)-9α,11α-epoxy-15-hydroxythromboxa-5,13-dien-1-oate