nicotinate beta-D-ribonucleotide

1. nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)

Catalysed by QPRT

1. 5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate

Catalysed by NAPRT

1. nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)

Catalysed by QPRTOne of 2 routes

1. nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate

Catalysed by NMNAT3, NMNAT2, NMNAT1

1. beta-D-ribosylnicotinate + ATP = nicotinate beta-D-ribonucleotide + ADP + H(+)

Catalysed by NMRK2, NMRK1

1. nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)
2. Nicotinate-nucleotide:pyrophosphate phosphoribosyltransferase (carboxylating)

Catalysed by QPRTcytosolOne of 4 routes

1. nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)
2. Orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase

Catalysed by QPRT, UMPScytosol

1. 5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate
2. orotate(out) + nicotinate(in) = orotate(in) + nicotinate(out)
3. (S)-dihydroorotate + a quinone = orotate + a quinol

Catalysed by NAPRT, SLC22A12, DHODHinner side of the membrane, outer side of the membrane

1. nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)
2. phosphoribosyl pyrophosphate amidotransferase (glutamine)
3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)