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Proteins/UNIPROT:Q8N4Q0
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation..
Function from UniProtKB (Q8N4Q0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
56 statements
56 statements · 4 reference databases · Subject: PTGR3 · Sources: gene ontology, Hetionet, Human-GEM, Rhea
8 reactions
NAD(+)+propane-1,2-diol(R)-lactaldehyde+proton+NADH(2-)
Catalysed by ADHFE1 or ADH6 or PTGR3 or ADH1A or ADH7 or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR08507CC BY 4.0Reference data
3 names
Resolves to: PTGR3
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR08508CC BY 4.0Reference data
NADP(3-)+13,14-dihydro-15-oxo-prostaglandin E2proton+NADPH(4-)+15-oxoprostaglandin E2
Catalysed by PTGR3
Reaction pageLeft to rightBalancedEC 1.3.1.48Golgi apparatus
Human-GEM MAR20018CC BY 4.0Reference data
NADP(3-)+13,14-dihydro-15-oxo-prostaglandin E2proton+NADPH(4-)+15-oxoprostaglandin E2
Catalysed by PTGR3
Reaction pageLeft to rightBalancedEC 1.3.1.48nucleus
Human-GEM MAR20019CC BY 4.0Reference data
13,14-dihydro-15-oxo-prostaglandin E2+NADP(3-)15-oxoprostaglandin E2+NADPH(4-)+hydron
Catalysed by PTGR1 or PTGR3 or PTGR2
Reaction pageRight to leftBalanced
Rhea RHEA:11912CC BY 4.0Reference data
CHEBI:133408+NADP(3-)15-oxoprostaglandin E1+NADPH(4-)+hydron
Catalysed by PTGR1 or PTGR3 or PTGR2
Reaction pageRight to leftBalanced
Rhea RHEA:50584CC BY 4.0Reference data
CHEBI:133374+NADP(3-)15-oxoprostaglandin F2alpha+NADPH(4-)+hydron
Catalysed by PTGR1 or PTGR3 or PTGR2
Reaction pageRight to leftBalanced
Rhea RHEA:50588CC BY 4.0Reference data
CHEBI:133411+NADP(3-)CHEBI:79072+NADPH(4-)+hydron
Catalysed by PTGR1 or PTGR3 or PTGR2
Reaction pageRight to leftBalanced
Rhea RHEA:50592CC BY 4.0Reference data