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Proteins/UNIPROT:P00492
Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
Function from UniProtKB (P00492), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
403 statements
403 statements · 9 reference databases · Subject: HPRT1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways · Rows fetched: 300
5 reactions
hypoxanthine+5-phospho-alpha-D-ribose 1-diphosphateCHEBI:17202+diphosphate(3-)
Catalysed by HPRT1
Reaction pageLeft to rightBalancedEC 2.4.2.8cytosol
Human-GEM MAR04418CC BY 4.0Reference data
guanine+5-phospho-alpha-D-ribose 1-diphosphateGMP+diphosphate(3-)
Catalysed by HPRT1
Reaction pageLeft to rightBalancedEC 2.4.2.8cytosol
3 names
Resolves to: HPRT1
5-phospho-alpha-D-ribose 1-diphosphate+xanthinediphosphate(3-)+XMP
Catalysed by HPRT1
Reaction pageLeft to rightBalancedEC 2.4.2.22cytosol
Human-GEM MAR04664CC BY 4.0Reference data
IMP+diphosphate(3-)hypoxanthine+5-phospho-alpha-D-ribose 1-diphosphate
Catalysed by HPRT1
Reaction pageRight to leftBalanced
Rhea RHEA:17973CC BY 4.0Reference data
GMP+diphosphate(3-)guanine+5-phospho-alpha-D-ribose 1-diphosphate
Catalysed by HPRT1
Reaction pageRight to leftBalanced
Rhea RHEA:25424CC BY 4.0Reference data