15-oxoprostaglandin D2

1. 15-dehydro-prostaglandin D2 reduction

No catalyst recordedcytosol

1. 15-dehydro-prostaglandin D2 reduction
2. prostaglandin J2 hydrolysis

No catalyst recordedcytosolOne of 2 routes

1. 15-dehydro-prostaglandin D2 reduction
2. transport of prostaglandin D2 (cytosol to extracellular)

Catalysed by SLCO1B1cytosol, extracellular spaceOne of 2 routes

1. 15-dehydro-prostaglandin D2 reduction
2. prostaglandin D2(out) + 2 (S)-lactate(in) = prostaglandin D2(in) + 2 (S)-lactate(out)

Catalysed by SLCO2A1cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

1. 15-dehydro-prostaglandin D2 reduction
2. transport of GSH and prostaglandin D2 (cytosol to extracellular)

Catalysed by SLCO2A1cytosol, extracellular spaceOne of 2 routes

1. 15-dehydro-prostaglandin D2 reduction
2. aldo-keto reductase (prostaglandin D2)

Catalysed by AKR1C3cytosolOne of 2 routes

1. 15-dehydro-prostaglandin D2 reduction
2. prostaglandin-D synthase (prostaglandin D2)

Catalysed by HPGDS, PTGDScytosol, endoplasmic reticulum

1. 15-dehydro-prostaglandin D2 reduction
2. prostaglandin D2 + NADPH + H(+) = 11beta-prostaglandin F2 + NADP(+)

Catalysed by AKR1C3, AKR1C2cytosol

1. 15-dehydro-prostaglandin D2 reduction
2. transport of prostaglandin D2 (cytosol to extracellular)
3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

1. 15-dehydro-prostaglandin D2 reduction
2. transport of prostaglandin D2 (cytosol to extracellular)
3. transport of glycoursodeoxycholate (cytosol to extracellular)