5-hydroxy-L-tryptophan

Three steps

• CHEBI:15611Reach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by TPH1, TPH2, SLC7A5, GNMTextracellular space, cytosol

• CHEBI:15650Reach from here →
  1. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2
  2. transport of serotonin (cytosol to extracellular)
  3. transport of leukotriene E4 (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 6 routes

• trimethylenediamineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of lysine and tryptophan (cytosol to extracellular)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by TPH1, TPH2, SLC7A6, DHPSextracellular space, cytosol

• CHEBI:15727Reach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of histidine and tryptophan (cytosol to extracellular)
  3. L-histidine:beta-alanine ligase (ADP-forming)

  Catalysed by TPH1, TPH2, SLC7A6, CARNS1extracellular space, cytosolOne of 2 routes

• formateReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. L-tryptophan + O2 = N-formyl-L-kynurenine
  3. N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)

  Catalysed by TPH1, TPH2, IDO1, TDO2 and 2 more

• CHEBI:15746Reach from here →
  1. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by DDC, AANAT, SAT1, SAT2cytosolOne of 2 routes

• CHEBI:15765Reach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of tryptophan and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by TPH1, TPH2, SLC7A5, THextracellular space, cytosolOne of 5 routes

• 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoateReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. Transport of 3-Hydroxy-L-Kynurenine
  3. 3-hydroxy-L-kynurenine:2-oxoglutarate aminotransferase

  Catalysed by TPH1, TPH2, SLC7A5, KYAT1 and 2 moreextracellular space, cytosol

• 3-hydroxyanthranilic acidReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. Transport of 3-Hydroxy-L-Kynurenine
  3. 3-Hydroxy-L-kynurenine hydrolase

  Catalysed by TPH1, TPH2, SLC7A5, KYNUextracellular space, cytosol

• bromideReach from here →
  1. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. 2-bromoacetaldehyde:glutathione S-(formylmethyl)transferase

  Catalysed by DDC, SLCO1A2, SLCO1B3, MGST3 and 16 moreextracellular space, cytosolOne of 2 routes

• N-carbamoyl-L-aspartic acidReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by TPH1, TPH2, SLC7A13, CADinner side of the membrane, outer side of the membrane, cytosol

• alpha-D-glucosamine 6-phosphateReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by TPH1, TPH2, SLC7A5, GFPT2 and 1 moreextracellular space, cytosol

• thioredoxin dithiolReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)
  3. glycyl-tRNA(gly) phosphorylation

  Catalysed by TPH1, TPH2, WARS1cytosolOne of 2 routes

• sulfateReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by TPH1, TPH2, SLC6A14, SLC26A6extracellular space, cytosolOne of 5 routes

• ureaReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of arginine and tryptophan (cytosol to extracellular)
  3. L-Arginine amidinohydrolase

  Catalysed by TPH1, TPH2, SLC7A6, ARG1extracellular space, cytosolOne of 3 routes

• L-cystineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by TPH1, TPH2, SLC7A5, SLC7A9 and 1 moreextracellular space, cytosolOne of 9 routes

• 11-cis-retinolReach from here →
  1. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by DDC, AANAT, DGAT1, LRAT and 3 morecytosol

• (R)-3-aminoisobutyric acidReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by TPH1, TPH2, SLC7A5, AGXT2extracellular space, cytosol, mitochondrial matrix

• lithocholic acidReach from here →
  1. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2
  2. transport of serotonin (cytosol to extracellular)
  3. transport of lithocholate (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• iodideReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of tryptophan and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by TPH1, TPH2, SLC7A5, TPOextracellular space, cytosolOne of 3 routes

• oxaloacetateReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. L-Aspartate:2-oxoglutarate aminotransferase

  Catalysed by TPH1, TPH2, SLC7A13, GOT2inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 6 routes

• nitric oxideReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of arginine and tryptophan (cytosol to extracellular)
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by TPH1, TPH2, SLC7A6, NOS3 and 2 moreextracellular space, cytosolOne of 2 routes

• CHEBI:16523Reach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by TPH1, TPH2, SLC7A5, SLC3A2 and 1 moreextracellular space, cytosolOne of 4 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by TPH1, TPH2, SLC7A6, ACY1extracellular space, cytosol

• 2-phenylacetamideReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of phenylalanine and tryptophan (cytosol to extracellular)
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by TPH1, TPH2, SLC7A5, EPXextracellular space, cytosol

• CHEBI:16633Reach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by TPH1, TPH2, SLC7A5, SCLYextracellular space, cytosol

• Met-tRNA(Met)Reach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by TPH1, TPH2, SLC7A5, MARS1extracellular space, cytosol

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by TPH1, TPH2, SLC7A5, AADATextracellular space, cytosol

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of phenylalanine and tryptophan (cytosol to extracellular)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by TPH1, TPH2, SLC7A5, CNDP2extracellular space, cytosol

• 2-oxobutanoateReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of threonine and tryptophan (cytosol to extracellular)
  3. L-threonine ammonia-lyase (2-oxobutanoate-forming)

  Catalysed by TPH1, TPH2, SLC7A5, SDS and 1 moreextracellular space, cytosol

• 2-oxoglutaramateReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by TPH1, TPH2, SLC7A5, KYAT1extracellular space, cytosolOne of 3 routes

• melatoninReach from here →
  1. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. S-adenosyl-L-homocysteine:N-acetylserotonin O-methyltransferase

  Catalysed by DDC, AANAT, ASMTcytosol

• glyoxylic acidReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by TPH1, TPH2, SLC7A5, DAOextracellular space, cytosol, peroxisome

• N-acetyl-L-aspartateReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by TPH1, TPH2, SLC7A13, NAT8Linner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• bilirubin IXalphaReach from here →
  1. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2
  2. transport of serotonin (cytosol to extracellular)
  3. transport of bilirubin (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• oxalic acidReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by TPH1, TPH2, SLC6A14, SLC26A6extracellular space, cytosol

• taurolithocholateReach from here →
  1. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2
  2. transport of serotonin (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• CHEBI:17208Reach from here →
  1. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. glutathione:dehydroascorbate oxidoreductase

  Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosol

• homocysteineReach from here →
  1. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. Formation of Homocystine

  Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosol

• L-glutamic 5-semialdehydeReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-Ornithine:2-oxo-acid aminotransferase

  Catalysed by TPH1, TPH2, SLC7A6, OATextracellular space, cytosol, mitochondrial matrix

• anilineReach from here →
  1. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by DDC, AANAT, NAT2, NAT1cytosol

• CHEBI:17312Reach from here →
  1. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by DDC, AANATcytosolOne of 2 routes

• D-aspartic acidReach from here →
  1. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2
  2. transport of serotonin (cytosol to extracellular)
  3. transport of D-aspartate (cytosol to extracellular)

  Catalysed by DDC, SLC6A4, SLC1A7, SLC1A3 and 3 moreextracellular space, cytosol

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of proline and tryptophan (cytosol to extracellular)
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by TPH1, TPH2, ABCA1, SLC7A5 and 1 moreextracellular space, cytosolOne of 2 routes

• agmatineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of arginine and tryptophan (cytosol to extracellular)
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by TPH1, TPH2, SLC7A6extracellular space, cytosol, mitochondrial matrix

• AH2Reach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by TPH1, TPH2, SLC7A5, MOCOSextracellular space, cytosolOne of 4 routes

• 5-aminolevulinic acidReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by TPH1, TPH2, SLC7A5, ALAS1 and 2 moreextracellular space, cytosol, mitochondrial matrix

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by DDC, AANAT, HADHA, ACADVL and 1 morecytosol, mitochondrial matrix

• Ala-tRNA(Ala)Reach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by TPH1, TPH2, SLC7A5, AARS1extracellular space, cytosol

• glycine betaineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by TPH1, TPH2, SLC6A14, SLC6A12extracellular space, cytosolOne of 3 routes