oxalic acid

Three steps

• CHEBI:16856Reach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, GSSextracellular space, cytosolOne of 2 routes

• glyoxylic acidReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, DAOextracellular space, cytosol, peroxisome

• creatineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Transport of Guanidinoacetic Acid
  3. S-Adenosyl-L-methionine:guanidinoacetate N-methyltransferase

  Catalysed by SLC26A6, GAMTextracellular space, cytosolOne of 2 routes

• ferrocytochrome cReach from here →
  1. transport of oxalate and sulfate (cytosol to extracellular)
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. sulfite:ferricytochrome-c oxidoreductase

  Catalysed by SLC26A6, SLC25A14, SLC25A30, SUOXextracellular space, cytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrix

• N-acetyl-L-aspartateReach from here →
  1. transport of oxalate and sulfate (cytosol to extracellular)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by SLC26A6, SLC25A14, SLC25A30, NAT8Lextracellular space, cytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• (R)-3-hydroxybutyric acidReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of (R)-3-hydroxybutanoate and formate (cytosol to extracellular)

  Catalysed by SLC26A6, SLC26A4, SLC16A4, SLC16A5 and 2 moreextracellular space, cytosolOne of 2 routes

• taurolithocholateReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. bile acid-CoA:amino acid N-acyltransferase (lithocholate)

  Catalysed by SLC26A6, SLC6A6, BAATextracellular space, cytosolOne of 2 routes

• estroneReach from here →
  1. transport of oxalate and sulfate (cytosol to extracellular)
  2. estrone 3-sulfate + H2O = estrone + sulfate + H(+)
  3. Estrone 3-sulfate sulfohydrolase

  Catalysed by SLC26A6, STSextracellular space, cytosolOne of 3 routes

• propanoateReach from here →
  1. transport of oxalate and sulfate (cytosol to extracellular)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. propanoate(out) + dehydroepiandrosterone 3-sulfate(in) = propanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by SLC26A6, STS, SLC22A9extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• linoleic acidReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC26A6, SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• D-aspartic acidReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. transport of D-aspartate (cytosol to extracellular)

  Catalysed by SLC26A6, SLC12A2, SLC12A1, SLC1A7 and 4 moreextracellular space, cytosol

• CHEBI:17380Reach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by SLC26A6, SLC6A14, SLC7A5extracellular space, cytosolOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Transport of L-Proline by the Apical Imino Amino Acid Transporters
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by SLC26A6, CLTRN, SLC6A20, PRODH2extracellular space, cytosolOne of 2 routes

• agmatineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by SLC26A6, SLC6A14extracellular space, cytosol, mitochondrial matrix

• enol-oxaloacetateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. Citrate Transport, Mitochondrial
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by SLC25A1, SDHB, SDHAmitochondrial matrix, cytosol

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. palmitoyl-CoA:L-carnitine O-palmitoyltransferase

  Catalysed by SLC26A6, SLC6A14, CPT2, CPT1Aextracellular space, cytosol, peroxisomeOne of 10 routes

• AH2Reach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)

  Catalysed by SLC26A6, SLC6A6, MTO1extracellular space, cytosolOne of 6 routes

• 5-aminolevulinic acidReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, ALAS1 and 2 moreextracellular space, cytosol, mitochondrial matrix

• diiodineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. iodide:hydrogen-peroxide oxidoreductase

  Catalysed by SLC26A6, SLC26A4, TPOextracellular space, cytosolOne of 2 routes

• indole-3-pyruvateReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by SLC26A6, SLC6A14, IL4I1extracellular space, cytosolOne of 2 routes

• 3,3'-diiodo-L-thyronineReach from here →
  1. transport of oxalate and sulfate (cytosol to extracellular)
  2. Steryl-Sulfatase
  3. Steryl-Sulfatase

  Catalysed by SLC26A6, STSextracellular space, cytosol, Golgi apparatusOne of 3 routes

• CHEBI:17724Reach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of betaine and chloride (cytosol to extracellular)
  3. Trimethylaminoacetate:L-homosysteine S-methyltransferase

  Catalysed by SLC26A6, SLC6A12, BHMT, BHMT2extracellular space, cytosol

• Ala-tRNA(Ala)Reach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC26A6, SLC6A14, AARS1extracellular space, cytosol

• trans-urocanateReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and histidine (cytosol to extracellular)
  3. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by SLC26A6, SLC6A14, HALextracellular space, cytosol

• urateReach from here →
  1. transport of oxalate and sulfate (cytosol to extracellular)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)

  Catalysed by SLC26A6, SLC25A35, SLC25A34, SLC22A6extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-hydroxy-L-tryptophanReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by SLC26A6, SLC6A14, TPH1, TPH2extracellular space, cytosol

• 4-methyl-2-oxopentanoateReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and leucine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC26A6, SLC6A14, BCAT2extracellular space, cytosol, mitochondrial matrixOne of 4 routes

• CHEBI:17927Reach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. Transport by Y+Lat-2 into Extracellular Space

  Catalysed by SLC26A6, SLC6A14, SLC3A2, SLC7A6extracellular space, cytosol

• 3-oxopropanoic acidReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of beta-alanine and chloride (cytosol to extracellular)
  3. beta-alanine:2-oxoglutarate aminotransferase

  Catalysed by SLC26A6, SLC6A6, SLC6A14, ABATextracellular space, cytosol, mitochondrial matrix

• butanoateReach from here →
  1. transport of oxalate and sulfate (cytosol to extracellular)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate(in) + butanoate(out) = dehydroepiandrosterone 3-sulfate(out) + butanoate(in)

  Catalysed by SLC26A6, STS, SLC22A9extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• 3-phenylpyruvateReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. Phenylalanine Transaminase, Mitochondrial

  Catalysed by SLC26A6, SLC6A14, GOT2, TATextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• thiocyanateReach from here →
  1. transport of oxalate and sulfate (cytosol to extracellular)
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by SLC26A6, SLC25A14, SLC25A30, SLC26A1 and 3 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 4-fumarylacetoacetateReach from here →
  1. transport of oxalate and sulfate (cytosol to extracellular)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by SLC26A6, SLC25A10, FAHextracellular space, cytosol, mitochondrial matrix

• dTTPReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of citrate and PEP (cytosol to mitochondria)
  3. pyruvate kinase (dTDP)

  Catalysed by SLC25A1, PKM, PKLRmitochondrial matrix, cytosol

• O-octanoyl-(R)-carnitineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. solute carrier (L-carnitine)

  Catalysed by SLC26A6, SLC6A14, SLC25A20extracellular space, cytosol, mitochondrial matrixOne of 7 routes

• CHEBI:18132Reach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and choline (cytosol to extracellular)
  3. ATP:choline phosphotransferase

  Catalysed by SLC26A6, SLC5A7, CHKA, CHKBextracellular space, cytosol

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, GARTextracellular space, cytosol

• 2-phenylethylamineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by SLC26A6, SLC6A14, DDCextracellular space, cytosol

• hydrogen cyanideReach from here →
  1. transport of oxalate and sulfate (cytosol to extracellular)
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by SLC26A6, SLC25A14, SLC25A30, MPST and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by SLC26A6, SLC6A14, PFASextracellular space, cytosol

• ophthalmateReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, GSSextracellular space, cytosol

• S-methylmercury-L-cysteineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. S-methylmercury-L-cysteine(in) + L-phenylalanine(out) = S-methylmercury-L-cysteine(out) + L-phenylalanine(in)

  Catalysed by SLC26A6, SLC6A14, SLC7A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-aminoisobutanoateReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by SLC26A6, SLC6A14, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-carboxy-4-methyl-5-propyl-2-furanpropanoateReach from here →
  1. transport of oxalate and sulfate (cytosol to extracellular)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)

  Catalysed by SLC26A6, SLC25A35, SLC25A34, SLC22A6 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-sepiapterinReach from here →
  1. transport of oxalate and sulfate (cytosol to extracellular)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)

  Catalysed by SLC26A6, SLC25A35, SLC25A34, SLC22A6 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. ATP citrate lyase (citrate)
  3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by SLC25A1, ACLY, AGXT2mitochondrial matrix, cytosol

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by SLC26A6, SLC6A9, SLC6A14, AGXT2extracellular space, cytosolOne of 2 routes

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by SLC26A6, SLC6A9, SLC6A14, SHMT1extracellular space, cytosolOne of 2 routes

• S-disulfanyl-L-cysteineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by SLC26A6, SLC6A14, CARS2extracellular space, cytosol

• N-acetylneuraminate 9-phosphateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of citrate and PEP (cytosol to mitochondria)
  3. N-acetylneuraminate synthase

  Catalysed by SLC25A1, NANSmitochondrial matrix, cytosolOne of 2 routes