5-(3,3-dimethylguanidino)-2-oxopentanoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

417 compounds within 3 steps: 7 in 1, 76 in 2, 334 in 3

One step

pyruvateReach from here →
1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
Catalysed by AGXT2
oxaloacetateReach from here →
1. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate
Catalysed by AGXT2
2-oxobutanoateReach from here →
1. N(omega),N(omega)-dimethyl-L-arginine + 2-oxobutanoate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + (2S)-2-aminobutanoate
Catalysed by AGXT2
2-oxopentanoateReach from here →
1. 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate
Catalysed by AGXT2
2-oxohexanoateReach from here →
1. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate
Catalysed by AGXT2
glyoxylateReach from here →
1. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
Catalysed by AGXT2
N(omega),N(omega)-dimethyl-L-arginineReach from here →
1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
Catalysed by AGXT2One of 6 routes

Two steps

CHEBI:1146900Reach from here →
1. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
Catalysed by AGXT2, CSmitochondrial matrixOne of 2 routes
2-hydroxybutyric acidReach from here →
1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. transport of 2-hydroxybutyrate and pyruvate (cytosol to extracellular)
Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol

One of 3 routes

acetoacetateReach from here →

Catalysed by AGXT2mitochondrial matrix, cytosolOne of 4 routes

N-octanoyl-(2S)-hydroxyglycineReach from here →

Catalysed by AGXT2, PAM

N-decanoyl-(2S)-hydroxyglycineReach from here →

Catalysed by AGXT2, PAM

N-dodecanoyl-(2S)-hydroxyglycineReach from here →

Catalysed by AGXT2, PAM

N-tetradecanoyl-(2S)-hydroxyglycineReach from here →

Catalysed by AGXT2, PAM

N-(9Z-octadecenoyl)-(2S)-hydroxyglycineReach from here →

Catalysed by AGXT2, PAM

N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycineReach from here →

Catalysed by AGXT2, PAM

acetylpyruvateReach from here →

Catalysed by AGXT2, FAHD1

all-trans-retinoic acidReach from here →

Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosolOne of 2 routes

propionyl-CoAReach from here →

Catalysed by AGXT2cytosol

(S)-malateReach from here →

Catalysed by AGXT2, ME2One of 8 routes

2-methyl-3-oxopropanoic acidReach from here →

Catalysed by AGXT2mitochondrial matrix

L-citrullineReach from here →

Catalysed by AGXT2, DDAH1cytosolOne of 2 routes

L-arginineReach from here →

Catalysed by AGXT2, SLC25A2inner side of the membrane, outer side of the membraneOne of 2 routes

(S)-lactateReach from here →

Catalysed by AGXT2, LDHA, LDHB, LDHC and 2 more

4-methylsulfanyl-2-oxobutanoateReach from here →

Catalysed by AGXT2, AADAT

2-oxoglutaramateReach from here →

Catalysed by AGXT2, KYAT1cytosolOne of 2 routes

3-fumarylpyruvateReach from here →

Catalysed by AGXT2, FAHD1

(R)-3-hydroxybutyric acidReach from here →

Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosolOne of 2 routes

3-hydroxypyruvateReach from here →

Catalysed by AGXT2, AGXT

aceneuramateReach from here →

Catalysed by AGXT2, NPL

5'-deoxyadenosineReach from here →

Catalysed by AGXT2, TYW1B, TYW1

indole-3-pyruvateReach from here →

Catalysed by AGXT2, AADAT

4-methyl-2-oxopentanoateReach from here →

Catalysed by AGXT2, AADAT

3-phenylpyruvateReach from here →

Catalysed by AGXT2, AADAT

dTDPReach from here →

Catalysed by AGXT2, PKM, PKLRcytosol

2-(alpha-Hydroxypropyl)thiamine diphosphateReach from here →

Catalysed by AGXT2, BCKDHA, BCKDHBmitochondrial matrix

5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →

Catalysed by AGXT2One of 2 routes

5-(3-methylguanidino)-2-oxopentanoateReach from here →

Catalysed by AGXT2One of 2 routes

selenomethionineReach from here →

Catalysed by AGXT2, CTHcytosol

CHEBI:27760Reach from here →

Catalysed by AGXT2, CTHcytosol

glycolateReach from here →

Catalysed by AGXT2, GRHPR

L-aspartateReach from here →

Catalysed by AGXT2One of 6 routes

acetateReach from here →

Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A3 and 2 moreextracellular space, cytosolOne of 2 routes

oxalateReach from here →

Catalysed by AGXT2, HAO1

formic acidReach from here →

Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A7 and 2 moreextracellular space, cytosolOne of 2 routes

propionic acidReach from here →

Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosolOne of 2 routes

citric acidReach from here →

Catalysed by AGXT2, CSmitochondrial matrixOne of 2 routes

butyric acidReach from here →

Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosolOne of 2 routes

3-hydroxypyruvic acidReach from here →

Catalysed by AGXT2, AGXTcytosolOne of 2 routes

4-hydroxy-2-oxoglutaric acidReach from here →

Catalysed by AGXT2, GOT2mitochondrial matrix