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Proteins/UNIPROT:Q9HA77
Mitochondrial cysteine-specific aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys)..
In addition to its role as an aminoacyl-tRNA synthetase, has also cysteine persulfide synthase activity. Produces reactive persulfide species such as cysteine persulfide (CysSSH) from substrate cysteine and mediate direct incorporation of CysSSH into proteins during translations, resulting in protein persulfides and polysulfides. CysSSHs behave as potent antioxidants and cellular protectants..
Function from UniProtKB (Q9HA77), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
2 rows
36 statements
36 statements · 5 reference databases · Subject: CARS2 · Sources: Bgee, Hetionet, Reactome, Rhea, UniProt
5 reactions
CHEBI:78442+L-cysteine+ATP(4-)CHEBI:78517+AMP+diphosphate(3-)
Reaction pageReversibleBalanced
Rhea RHEA:17773CC BY 4.0Reference data
2L-cysteineS-sulfanyl-L-cysteine+L-alanine
Catalysed by CARS2
Reaction pageLeft to rightBalanced
2 names
Resolves to: CARS2
S-sulfanyl-L-cysteine+L-cysteineS-disulfanyl-L-cysteine+L-alanine
Catalysed by CARS2
Reaction pageLeft to rightBalanced
Rhea RHEA:78627CC BY 4.0Reference data
S-sulfanyl-L-cysteine+CHEBI:78442+ATP(4-)CHEBI:229520+AMP+diphosphate(3-)
Catalysed by CARS2
Reaction pageLeft to rightBalanced
Rhea RHEA:78647CC BY 4.0Reference data
S-disulfanyl-L-cysteine+CHEBI:78442+ATP(4-)CHEBI:229521+AMP+diphosphate(3-)
Catalysed by CARS2
Reaction pageLeft to rightBalanced
Rhea RHEA:78651CC BY 4.0Reference data