5,6,7,8-tetrahydrofolic acid

1. Formate:tetrahydrofolate ligase (ADP-forming)

Catalysed by MTHFD1cytosolOne of 3 routes

1. histamine N-methyltransferase (SAM)

Catalysed by HNMTcytosol

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

Catalysed by SHMT1cytosolOne of 5 routes

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

Catalysed by SHMT1cytosolOne of 3 routes

1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase

Catalysed by DHFR, DHFR2cytosolOne of 3 routes

1. 5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase

Catalysed by FTCDcytosol

1. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)

Catalysed by ATICcytosol

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase

Catalysed by SHMT1, BAATcytosol, peroxisomeOne of 28 routes

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine

Catalysed by SHMT1, AGXT2cytosol